Q32 Bio Inc.

Cheng Ran Huang

Justin Andrew Caravella

Frederick Robbins Taylor

Susan L Kalled

Shelia Marie Violette

Vernon Michael Holers

Michael Storek

Ellen Garber Stark

Michael Steven Curtis

Kelly C Fahnoe

Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Further provided are methods of using the fusion protein constructs, for example, in treating complement mediation conditions.

Methods of treating complement mediated diseases with fusion protein constructs comprising anti-C3d antibody and a complement modulator

Fusion protein constructs comprising anti-C3d antibody and CR1 polypeptide

Fusion protein constructs comprising anti-C3d antibody and factor H

Growing community of inventors

Belmont, MA, United States of America

Cheng Ran Huang