Tufts College

Nantong University

Simatech Incorporation

Cheng Qian

David L Kaplan

Jian Liu

Xiaoqin Wang

Yan Zhang

Haijun Zhang

Hong Dai

Dandan Zheng

Heyi Miao

Yang Wang

Zhaozhu Zheng

Beibei Zhou

Shaozhe Guo

Meiling Huang

Jianbing Wu

Fuxin Shi

Yong Ling

The disclosure relates to a preparation method and use of a pyrazole compound containing 1-(3,4-dimethoxyphenyl)-β-carboline unit. The pyrazole compound is prepared by reacting pyrazole aldehyde and 1-(3,4-dimethoxyphenyl)-β-carboline acylhydrazine. The pyrazole compound containing 1-(3,4-dimethoxyphenyl)-β-carboline unit has good inhibitory activity against tumor cell HGC-27. The pyrazole compound could be used in the preparation of anti-tumor drugs.

Preparation method and use of pyrazole compound containing 1-(3,4-dimethoxyphenyl)-β-carboline unit

The invention discloses a freeze-dried powder of high molecular weight silk fibroin, preparation process and use thereof. The freeze-dried powder is obtained from silk by degumming, dissolution, dialysis, centrifugation, high temperature and high pressure treatment and freeze-drying. A method of preparing silk fibroin microspheres with polyethylene glycol comprises mixing a silk fibroin solution of 1-30 wt % with a PEG solution of 10-60 w % and incubating the resulting solution. A controlled-release or sustained-release silk fibroin gel formulation includes a gel-state carrier and a drug dispersed/adsorbed therein, the carrier is a silk fibroin gel formed by blending with LMW-PEG. The freeze-dried powder will not change the native molecular weight and random coil structure of silk fibroin, and can be rapidly dissolved into a solution, and can be stored and transported for a long time, and this reduces waste of silk fibroin materials and promotes R & D and biomedical applications of silk fibroin biomaterials.

Freeze-dried powder of high molecular weight silk fibroin, preparation method therefor and use thereof

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Jiangsu, China

Cheng Qian