Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.o.c

Cheng-Liang Peng

Tsai-Yueh Luo

Ming-Cheng Chang

Kun-Liang Lin

Kuan-Yin Chen

Chien-Chung Hsia

Chung-Hsin Yeh

Chun-Tang Chen

Siao-Syun Guan

Tse-Zung Liao

Disclosed herein is a complex, a contrast agent and the method for treating a disease related to CXCR4 receptor. The complex is configured to bind the CXCR4 receptor, and is used as a medicament for diagnosis and treatment of cancers and other indications related to the CXCR4 receptor.

Complex, contrast agent and method for treating a disease related to CXCR4 receptor

Disclosed herein are a dual-targeted carbonic anhydrase IX complex, a contrast agent comprising the same, and a synthesizing method thereof. The dual-targeted carbonic anhydrase IX complex includes a carbonic anhydrase IX (CA9) binding peptide, a sulfonamide derivative, and a metal chelating agent. The dual-targeted carbonic anhydrase IX complex has potential for use as a molecular nuclear drug.

Dual-targeted carbonic anhydrase ix complex and contrast agent thereof

The present invention provides an ophthalmic gel and a preparation method thereof. The ophthalmic gel comprises: an antibiotic; a nanocarrier, wherein the nanocarrier is used to load the antibiotic; and a biodegradable matrix, wherein the biodegradable matrix is compatible with the nanocarrier to carry the nanocarrier. When the ophthalmic gel of the present invention is applied to the surface of the cornea and conjunctiva of the eyes, the biodegradable matrix is automatically degraded and the nanocarrier carried by the biodegradable matrix will slowly release the antibiotic, loaded in the nanocarrier, at an appropriate rate to overcome the high-frequency use of general ophthalmic drugs and easily caused blurred vision; the present invention further comprises an ophthalmic gel preparation method.

Ophthalmic gel and preparation method thereof

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Taoyuan, Taiwan

Cheng-Liang Peng