Great Novel Therapeutics Biotech & Medicals Corporation

Far Eastern New Century Corporation

Cheng-Han Chou

Chia-Nan Chen

Ye-Su Chao

Yi-Hong Wu

Jia-Shiong Chen

Mu-Hsuan Yang

Sz-Hao Chu

Xin-An Lu

Fa-Chen Chi

Guei-San Chen

The present disclosure generally relates to compounds class I HDAC inhibitors, their production and applications. The compounds possess epigenetic immunomodulatory activities in the tumor microenvironment (TME) and thus inhibit growth of tumor cells.

Histone deacetylase inhibitors for immunomodulation in tumor microenvironment

The present invention relates to a combination of a histone deacetylase (HDAC) inhibitor, chidamide in an acidic salt form, and a nonsteroidal anti-inflammatory drugs (NSAIDs), celecoxib in a basic salt form. The present invention also relates to methods which significantly regulate tumor microenvironment and therefore dramatically improve anti-cancer activity.

Anticancer combination of chidamide and celecoxib salts

A method for producing terephthalic acid comprises the steps of: subjecting methyl acrylate to contact with aluminum chloride so as to form a complex; adding isoprene to the complex to result in a Diels-Alder reaction which is kept at a temperature no higher than 50&#xb0; C. by cooling so as to obtain a cyclic adduct product; subjecting the cyclic adduct product to separation so as to obtain a cyclic para-precursor; and subjecting the cyclic para-precursor to a chemical reaction so as to obtain terephthalic acid.

Method for producing terephthalic acid

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Taipei, Taiwan

Cheng-Han Chou