Bristol-myers Squibb Compnay

Obi Pharma Inc.

Microbio Co. Ltd.

Cheng Der Yu

Bhiku Patel

Yu-Hsin Lin

Yu-Chen Lin

Prakash V Parab

I-Ju Chen

Cheng-Chi Wang

Hemanshu S Shah

Yih-Huang Hsieh

Nan-Hsuan Wang

Susan Genier

Chung-Hao Chang

Wei Han Lee

Ming-Hong Chuang

Kung-Ming Lu

The invention provides methods and means for enhancing the epidermal, transdermal and dermal permeation of a topically applied pharmacologically active agent (e.g., a drug or medicament) which has a low rate of skin penetration in the absence of a permeation enhancer and which is unstable and degrades during long-term storage with particular permeation enhancers. Also provided by the invention are methods and means to increase the skin penetration of a pharmacologically active agent which has a normally low rate of skin permeation and causes the instability and degradation of a permeation enhancer with which it is combined over a long period of time. Provided by the invention are at least one first composition containing a drug, a pharmaceutically acceptable salt, chemical derivative or formulation thereof, in a dermatologically acceptable vehicle, and at least one second composition containing a permeation enhancer in an acceptable vehicle. The compositions are physically separated until application to a body or skin surface and are topically applied, either at the same time, or sequentially within a short time of each other, and mixed or blended to form a final active composition, preferably on the skin. In addition, a premixture of the compositions can be made and applied to the skin in accordance with the invention. The invention allows a therapeutically effective amount of drug to be delivered into the skin and systemic circulation and provides significant enhancement of a drug's otherwise low level of skin permeation by the action of permeation enhancer in the active composition at the point of use.

Methods and compositions for enhancing skin permeation of drugs using

A gel formulation for topical administration with enhanced skin penetration properties comprising a therapeutically effective amount of an imidazole antifungal agent, either by itself or in combination with a steroid anti-inflammatory agent, in a vehicle system that includes lauryl alcohol is disclosed.

Lauryl alcohol as skin penetration enhancer for topical imidazole agents

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Cheng Der Yu