National Yang Ming Chiao Tung University

Cheng Allen Chang

Keng-Li Lan

Hsin-Ell Wang

Shun-Fu Chang

Jia-Je Li

Pei-Chia Chan

Ren-Shyan Liu

Bhalchandra Vishnu Bhagwat

A dual targeting drug carrier is provided. The dual targeting drug carrier comprises a first targeting molecule and a second targeting molecule, wherein the targeting molecule comprises peptide, protein or antibody. The targeting molecule can bind to specific receptors, proteins, or glycoproteins to recognize the specific tumor cells, tissues, or organs. The dual targeting drug carriers are further conjugated with imaging agents, radioactive molecules (radiopharmaceuticals, isotopes, or chemotherapeutic drugs) or nanoparticles to form a conjugate.

Dual targeting drug carrier and application thereof

The present disclosure provides a novel class of macrocyclic compounds and their metal complexes formed with transition metal ion, lanthanide metal ions and other metal ions (e.g., Al, Ga, Y, In, Sn, Tl, Pb and Bi) and their applications in the fields of contrast agents, artificial nucleases, fluorescence probes, nuclear medicines and other biomedical applications in the therapeutics or diagnostics.

Macrocyclic compounds and metal complexes for bioimaging and biomedical applications

Growing community of inventors

Taipei, Taiwan

Cheng Allen Chang