The Brigham and Women's Hospital, Inc.

Beth Israel Deaconess Medical Center, Inc.

Emisphere Technologies, Inc.

Chen Zhu

Vijay K Kuchroo

Terry Barton Strom

Xin Xiao Zheng

Sumone Chakravarti

Alberto Sanchez-Fueyo

Eugene K Cha

Yi Heng Chen

David Gschneidner

Kelly Sullivan Kraft

Richard S Blumberg

Ana Carrizosa Anderson

Catherine Anne Sabatos-Peyton

Yi C Chen

Yu-Hwa Huang

Catherine Sabatos

Yi Chen

Alberto Sanchez-Fuego

Described herein are compositions and methods for the modulation of T-cell tolerance, which can be upregulated or down regulated by concurrent enhancement or inhibition of CEACAM1/TIM3 interactions. As described herein, the discovery that CEACAM1 is a direct ligand of TIM3 and vice versa has been shown in cis and in trans. In addition, as demonstrated herein, CEACAM1 and TIM3 are co-regulated during the course of T-cell activation.

Modulation of the immune response

The invention relates to isolated polypeptides and nucleic acids encoding polypeptides which comprise a tim-3 IgV domain and a tim-3 intracellular domain, wherein the polypeptides do not comprise a tim-3 mucin domain or a tim-3 transmembrane domain. In addition, the invention relates to methods of modulating immune responses in a subject, comprising administering to the subject a therapeutically effective amount of an agent that modulates tim-3 activity. Immune responses include, but are not limited to, immune tolerance, transplantation tolerance, Th1 responses and Th2 responses.

TIM-3 ligands and methods of modulating immune responses

Tim-3 ligands and methods thereof

Phenoxy amine compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

Phenoxy amine compounds and compositions for delivering active agents

Growing community of inventors

Brookline, MA, United States of America

Chen Zhu