Chengdu University of Technology

Sichuan Haisco Pharmaceutical Co., Ltd.

Haisco Pharmaceuticals Pte. Ltd.

Sichuan University

Chen Zhang

Yiquan Ma

Fei Ye

Pangke Yan

Jianmin Wang

Lei Chen

Yao Li

Huaguo Wen

Chao Ma

Pingming Tang

Jintong Liang

Yixin Dong

Shaohui Wang

Xin Wang

Yonggang Wei

Bo Xu

Yuan Zhong

Xin Liu

Gang Zhou

Zongjun Shi

Xiangye Kong

Wei Wei

Yongchao Lu

Wenbin Tang

Yangbo Lu

Xiaobo Zhang

Wenjing Wang

Jia Ni

Bolin Zhang

Zhenggang Huang

Yajun Wang

Yunchuan Zeng

Guobiao Zhang

Dengyu Zheng

Hao Wang

Wei Zheng

Lan Yang

Wei Yan

Guozhi Zhu

Mingyu Zheng

Ying Guo

Xiaogang Chen

Anbang Huang

Qinyu Cui

Shoutao Wu

Ke Zhao

Jingyu Zhang

Yi Shu

Zhanhong Liu

Longbin Huang

Xuebin Du

Xiaofeng Liu

Lingna Shi

Xiaojie Fan

Caihu Li

Mengtian Gao

Caiguang Zhi

Jing Nie

Yiting Sun

Xia Zhang

Dawen Niu

Liqiang Wan

Demeng Xie

Yuting Liao

Ya Zhang

Ziqi Feng

Disclosed is a nitrile derivative compound represented by formula (I), a stereoisomer, a deuterated product, a co-crystal, a solvate or a pharmaceutically acceptable salt thereof, wherein each group is as defined in the description. The compound has dipeptidyl peptidase 1 inhibitory activity and can be used to prepare a drug for treating diseases including obstructive airway diseases, bronchiectasis, cystic fibrosis, asthma, emphysema, and chronic obstructive pulmonary diseases.

Nitrile derivative that acts as inhibitor of dipeptidyl peptidase 1 and use thereof

The invention provides a fracture opening simulation device for hard brittle mudstone and shale with organic matter, it includes a simulated support, the lower part of the simulated support is connected with a storage bucket bottom block plate through a screw, the middle of the simulated support is provided with a support socket with a circular structure, the upper surface of the storage bucket bottom block plate is provided with a circular convex structure of a block plate boss, the block plate boss is closely inserted in the support socket, the upper surface of the simulated support is fixed connected with a core column storage barrel.

Fracture opening simulation device for hard brittle mudstone and shale with organic matter

A glycosyl donor represented by formula (I) is used for preparing an S-glycoside compound represented by formula (III), an O-glycoside compound represented by formula (V), and a C-glycoside compound represented by formula (V). The glycosyl donor is a raw material in the preparation of O-glycoside, S-glycoside, and C-glycoside compounds by means of a free radical reaction, most of which have a special α configuration.

Glycosyl donor, preparation method therefor, and use thereof

The invention provides a sampling device for geological fluid detection, relates to the technical field of fluid detection. The sampling device comprises a support frame, the support frame is of an L-shaped structure, and a second support plate is arranged at an upper portion of the support frame; the protection cover is mounted at the corner of a bottom portion of the support frame. The water fixing member is clamped above the bottom portion of the support frame; the locking inclined block is mounted at the bottom portion of the; and the detector is provided with a water inlet pipe. Fluid at different depths is detected through cooperation of the mounting sleeve and the lifting frame, a fluid drainage tube is wound around the winding wheel, the mounting sleeve is driven by the lifting frame to adjust the position through the arrangement of the gear and the rack, the fluid is sampled through the sampling test tube.

Sampling device for geological fluid detection

The present invention provides a multifunctional rock mechanics tester, pertaining to the technical field of mechanics tester, consisting of a base; wherein a power mechanism is mounted on the top of the base, two tension testing mechanisms are arranged on the power mechanism in an up-and-down symmetrical way, a clamping mechanism is mounted on each tension testing mechanism, a rock testing block is clamped between the two clamping mechanisms. The present invention realizes the tension and pressure testing of the rock test block through the arrangement of tension testing mechanism and pressure testing mechanism, thus improving the functionality of the present mechanics tester, which not only reduces the testing cost, but also effectively decreases the occupied space; the present invention solves the problem that the traditional mechanics tester can only complete one kind of test when it is used.

Multifunctional rock mechanics tester

The present disclosure discloses a classification method and system for fine-grained mixed sedimentary rocks, a medium and a terminal. Core description and thin section observation are used to accurately identify the sedimentary structure types and their vertical distribution characteristics from the macroscopic and microscopic perspectives, and indicates the mixed sedimentation characteristics of combination of different lamina or laminar couplets. The micro-drilling sampling technique is used to sample the samples with different types of sedimentary structures while avoiding diagenetic minerals. X-ray diffraction mineral content analysis and a high-precision carbon-sulfur analyzer are used to obtain the contents of different types of minerals and the total organic carbon contents in each sample, respectively, the basic rock type of each sample was determined using a triangular classification diagram. The name of sedimentary structure and the total organic carbon content are added in order before the name of the basic rock type.

Classification method and system for fine-grained mixed sedimentary rocks, medium, and terminal

Disclosed is a multi-shaft pressurized rock mechanics tester, pertaining to the technical field of rock mechanics testing devices, comprising a base; the base is of an integral rectangular structure, and welded six vertical support plates symmetrically at the front and back ends, a-shaped bracket plate is horizontally welded at the top of the six vertical support plates ('' is a Chinese character, read as “Ri”), and a bracket plate is rotatably installed on the top section of the three rear vertical support plates, pressed against the-shaped bracket plate; the left and right sides of the base are symmetrically welded with four vertical bracing plates, an I-shaped installation plate is welded on the top of the four vertical bracing plates, four hydraulic cylinders are locked, fixed and hoisted on the bottom of the I-shaped installation plate with screws.

Multi-shaft pressurized rock mechanics tester

Substituted piperidines as BTK inhibitors, a preparation method thereof and a pharmaceutical application thereof. The substituted piperidines is a compound represented by a general formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof, and the substituted piperidines is used to treat BTK-related diseases such as tumors or autoimmune system diseases.B-L-K&#x2003;&#x2003;formula (I)

Substituted piperidines as BTK inhibitors

The invention provides a peptide amide compound represented by the general general formula (I), a preparation method thereof, and a medical application thereof. The compound has a novel structure, better biological activity, and better analgesic effect. 

Peptide amide compound and preparation method and medical use thereof

The present invention relates to a crystal form of a substituted aminopyran compound, and a pharmaceutical composition, a preparation method and a use thereof in the preparation of a drug for treating type II diabetes. In particular, the present invention relates to a crystal form IV of a compound as shown by formula (I) and a pharmaceutical composition, a preparation method and a use thereof in the preparation of a drug for treating type II diabetes. 

Crystal form of substituted aminopyran derivativek

The present disclosure relates to an amino pyran ring derivative and a composition and use thereof, and in particular, to an amino pyran ring derivative represented by general formula (I) or a stereoisomer, a pharmaceutically acceptable salt or a prodrug thereof, a pharmaceutical composition comprising the derivative, and their medical use in the manufacture of a di-peptidyl peptidase IV (DPP-IV) inhibitor, in formula (I) the substituents are defined the same as those in the specification.

Amino pryan ring derivative and composition and use thereof

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Chengdu, China

Chen Zhang