National Cheng-Kung University

Other

Chen-Sheng Yeh

Dar-Bin Shieh

Ping-Ching Wu

Jih Ru Hwu

Wu-chou Su

Tsung-Ju Li

Liu-Chun Wang

Yu-Sern Lin

Chih-Chia Huang

Fong-Yu Cheng

Dong-Hwang Chen

Ya-Na Wu

Chia-Hao Su

Wei-Peng Li

Zheng-Zhe Chen

Pei-Jane Tsai

Wei-Ting Lee

Shang-Rung Wu

Ming-Fong Tsai

Disclosed herein is a method for producing a nanoframe of Prussian blue (PB) or an analogue thereof (PBA). The producing method comprises: (a) mixing a nanocube of PB or PBA with an acid solution to form a mixture; and (b) heating the mixture of the step (a) in an oil bath at 80-100° C. for 0.5 hours-1 month to produce the nanoframe of PB or PBA. Also encompassed herein is a method for treating a cancer in a subject in need thereof, which comprises administering an effective amount of a nanocube or a nanoframe of PB or PBA to the subject.

Methods for treating cancers by using nanoframes of Prussian blue or an analogue thereof and its production methods

Disclosed herein are modified chromium-dpoed zinc gallate (ZGC) nanocubes, which are characterized in respectively having a concave surface that is modified with (3-aminopropyl)triethoxysilane (APTES). The modified ZGC nanocubes produce long lasting luminescence (LLL) that lasts for at least 1.5 hours under X-ray or UV excitation. Also disclosed herein are methods for the preparation of the modified ZGC nanocubes; and methods for imaging an area of interest (e.g., cancer) in a live subject using the modified ZGC nanocubes as an imaging agent.

Modified chromium-doped zinc gallate nanocube, its preparation method and uses thereof

Disclosed herein is a use of FeOnanoparticle in inhibiting the spore germination of. The FeOnanoparticle specifically targets the spores ofspores by damaging and breaking the intact structure of thespores. Further, the FeOnanoparticle possesses superior sporicidal activity, as compared to other known bactericidal nanoparticles. Therefore, the FeOnanoparticle of the disclosure is useful as a bactericide or more specifically, a sporicide to treatinfection for its superior sporicidal activity.

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A nanostructure is described. The nanostructure includes a nanoparticle, a shell encompassing the nanoparticle, and a gap having a width ranging from 1.0 nm to 6.0 nm and located between the nanoparticle and the shell to enable the nanostructure to generate a fluorescence.

Nanostructure, applied device and preparation method thereof

The present invention relates to a magnetic nanoparticle for tumor therapy, comprising: a magnetic core; a shell encapsulating a surface of the magnetic core, wherein the shell is made of a polymer with carboxylic groups; a poly-nucleotide chain connected to a surface of the shell; an anti-tumor drug connected to the poly-nucleotide chain, wherein the anti-tumor drug comprises at least one functional group, and each of the functional group is independently a pyrimidine group or a purine group; and an antibody connected to the shell, wherein the antibody identifies a target tumor. In addition, the present invention further provides a method for manufacturing the magnetic nanoparticles for tumor therapy and a pharmaceutical composition containing the magnetic nanoparticles. Accordingly, the magnetic nanoparticle for tumor therapy of the present invention can achieve effective treatment of tumor by synergistic effects between hyperthermia and targeted chemotherapy.

Radiofrequency-induced synchronization of in situ hyperthermia and chemotherapy via magnetic-nanoconjugates

A phosphate-containing nanoparticle delivery vehicle includes nanoparticle, an active ingredient, and a phosphodiester moiety connecting the nanoparticle and the active ingredient and forms a prodrug. The nanoparticle delivery vehicle achieves the function of increasing hydrophilicity of the active ingredient and specificity against tumor cells. Advantages of the nanoparticle material include biocompatibility, magnetism and/or controllable drug release.

Phosphate-containing nanoparticle delivery vehicle

A phosphate-containing nanoparticle delivery vehicle includes a nanoparticle, an active ingredient, and a phosphodiester moiety connecting the nanoparticle and the active ingredient and forms a prodrug. The nanoparticle delivery vehicle achieves the function of increasing hydrophilicity of the active ingredient and specificity against tumor cells. Advantages of the nanoparticle material include biocompatibility, magnetism and/or controllable drug release.

The present invention relates to a nano-carrier for an anticancer drug, which comprises: a metal nanoparticle; and a polynucleotide for connecting with an anticancer drug having a pyrimidine group or a purine group, wherein the polynucleotide connects to a surface of the metal nanoparticle, and the anticancer drug binds to the polynucleotide through the pyrimidine group or the purine group. In addition, the present invention also provides a complex of an anticancer drug and a nano-carrier, a pharmaceutical composition thereof, a method for manufacturing the complex, and a method for treating a cancer by using the pharmaceutical composition.

Nano-carrier, complex of anticancer drug and nano-carrier, pharmaceutical composition thereof, method for manufacturing the complex, and method for treating cancer by using the pharmaceutical composition

Growing community of inventors

Tainan, Taiwan

Chen-Sheng Yeh