Viva Biotech (Shanghai) Ltd.

Technoderma Medicines Pte Ltd.

Chen Mao

Sheldon Cao

Xiaodong Cao

Na Li

Jian Shen

Min Han

Fan Jiang

Xiuhong Zeng

Xiaoyan Su

Delin Ren

Jianhua Cai

Wentao Wei

Zengquan Wang

The present invention relates to fusion proteins for the expression of G-protein coupled receptor proteins (GPCR) with the fusion partners, as inserted fragments, from mammalian cells. The fusion partners are from a fragment of APJ protein ('the APJ protein fragment') or a fragment with homology of more than 90% similarity to the APJ protein fragment; or a fragment of RGS16 protein (the 'RGS16 protein fragment') or a fragment with homology of more than 90% similarity to the RGS16 protein fragment; or the fragment of DNJ protein (the &#x201c;DNJ protein fragment&#x201d;) or a fragment with homology of more than 90% similarity to DNJ protein fragment. The fusion expression of GPCR with the above mentioned fusion partners can improve the protein yield and stability when purified from cells. Therefore, these fusion protein partners can be widely used for the study of GPCR proteins.

Method of expressing a G-protein coupled receptor protein

Nucleic acid sequence encoding a fusion protein

Provided is a small molecule compound as represented by structural formula (I). The product of the present invention in various concentrations and dosages can achieve an obvious change in the growth period of hairs, promoting the growth of the hairs, thus exhibiting an obvious effect of promoting hair growth. In addition, changes in the weight of a mouse in each group are slow, indicating that the test compound does not cause weight loss in an animal.

Small molecule compound and synthesizing method and uses thereof

Fusion expression of G-protein coupled receptor

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Shanghai, China

Chen Mao