Shanghai Institute of Pharmaceutical Industry

Shanghai Modern Pharmaceutical Engineering Research Center Co., Ltd.

Chen Ge

Yue Zhang

Jun He

Yuan Zhao

Bing Yi

Yuezhu Zhao

Jiuhui Zhang

Yani Yang

Minghao Niu

Qinghui Fu

Zhefeng Wang

Wei Bian

A phenyl-containing compound, an intermediate thereof, a preparation method therefor and an application thereof. Provided is a compound represented by formula I or a pharmaceutically acceptable salt thereof, where R, R, R, Rand Rare independently hydrogen, C-Calkyl, C-Calkoxy or C(&#x2550;O)OR; where Ris C-Calkyl; Ris (II), (III) or (IV); and Ris &#x2014;OH, &#x2014;NH, &#x2014;NHCH, &#x2014;N(CH)or Calkoxy. The compound has a low critical micelle concentration (CMC) and good dilution resistance and is capable of enclosing an insoluble drug to form a small-molecule micelle having a high drug loading capacity and good stability. 

Phenyl containing compound, intermediate thereof, preparation method therefor and application thereof

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Shanghai, China

Chen Ge