Gilead Sciences, Inc.

Rivian IP Holdings, LLC

Chen Chen

William John Watkins

Chandrasekar Venkataramani

Peter A Blomgren

Musong Kim

Zhimin Du

Suet Chung Yeung

Julian Andrew Codelli

Gayatri Balan

Rhiannon Thomas-Tran

Gregg M Schwarzwalder

Helen Yu

Michael T Tudesco

Dorothée Saddier Axe

Brian M Weist

Rubayyat Mahbub

Forrest Stephen Gittleson

Shyam Dwaraknath

Thomas Andrew Wynn

Sonika Rajput

Hui Dong

The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.

IKAROS Zinc Finger Family degraders and uses thereof

Aspects of the disclosure relate to solid state electrolytes which include a composition of LiPSCl having a dopant substituted, in part, for phosphorus (P-site dopant) and an excess molar amount of Cl (i.e., doped, off-stoichiometric compositions). The P-site dopant can be selected among Groups 4, 5, 14, or 15 of the periodic table of elements and has an ionic radius greater than phosphorus (P). Such solid state electrolytes can be used in all solid-state batteries and configured for use in electric vehicles.

Solid state electrolyte

IKAROS zinc finger family degraders and uses thereof

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Newark, CA, United States of America

Chen Chen