Syntex (u.s.a.) Inc.

Chee-Liang L Gu

Peter H Nelson

William A Lee

Anthony C Allison

Elsie M Eugui

Heterocyclic aminoalkyl esters of mycophenolic acid, and the derivatives and pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, anti-inflammatory agents, anti-tumor agents, anti-viral agents, and anti-psoriatic agents.

Treatment of autoimmune inflammatory, and psoriatic diseases with

The compounds and pharmaceutical compositions of Formula A, wherein Z is hydrogen or --C(O)R, Y is hydrogen or morpholinoethyl, and where R is lower alkyl or aryl, and the pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, particularly for treatment of allograft rejection, especially including cardiac allograft rejection, pancreatic allograft rejection and renal allograft rejection, and for treating autoimmune diabetes. ##STR1##

Treatment of autoimmune diseases with mycophenolic acid, and derivatives

The compounds and pharmaceutical compositions of Formula A, wherein Z is hydrogen or --C(O)R, where R is lower alkyl or aryl, and the pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, anti-inflammatory agents, anti-tumor agents, anti-viral agents, and anti-psoriatic agents. ##STR1##

Method of treating diseases by administering morpholino-ethylester of

Treatment of autoimmune diseases with the morpholinoethyl ester of

Treatment of allograft rejection with mycophenolic acid, its

Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives

Method of treating diseases by administering morpholinoethylester of

Treatment of allograft rejection with mycophenolic acid

Morpholinoethylesters of mycophenolic acid and pharmaceutical

Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof

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Sunnyvale, CA, United States of America

Chee-Liang L Gu