Original Biomedicals Co., Ltd

Taiwan Hopax Chems. Mfg. Co., Ltd.

Chau-Hui Wang

Chia-Hung Chen

Jing-Yi Chen

Wei-Chuan Liao

Johnson Lin

Chia-Chi Su

John-Son Lin

Tieh-Hsiung Chiu

Pi-Hung Liao

Chih-Wei Hsu

Jing Yi Chen

The present invention features a method for reducing the damage caused by free radicals, the method comprises administering a pharmaceutical composition that comprises at least a metal or its ions, at least a drug or an antioxidant that is carrier-protected/modified, and a drug carrier to a subject. Said carrier helps to preserve the anti-oxidative activity, and hence, prevents the decrease of the effect of the antioxidant against free radicals produced in the environment or body fluids and prolongs protection, and be used for reducing damage caused by radiation and adverse effects induced by chemotherapeutic drugs.

Method for reducing damage caused by free radicals

The present invention features a pharmaceutical composition used for reducing the damage caused by free radicals, which comprises at least a metal or its ions, at least a drug or an antioxidant that is carrier-protected/modified, and a drug carrier. Said carrier helps to preserve the anti-oxidative activity, and hence, prevents the decrease of the effect of the antioxidant against free radicals produced in the environment or body fluids and prolongs protection, and may be used for reducing damage caused by radiation and adverse effects induced by chemotherapeutic drugs.

Pharmaceutical composition used for reducing damage caused by free radicals

This invention provides the controlled-release method for a pharmaceutical composition comprising of metals in the drug carrier. The specific chelator is used to trigger the release of active pharmaceutical ingredients from chelating complex micelles. The drug release rate and half-life can also be controlled by manipulating the dosing sequence and the concentration of metal and specific chelator.

Controlled release method for a pharmaceutical composition composed of chelating complex micelles

This invention provides Chelating Complex Micelles as a drug carrier. The Chelating Complex Micelles can load drugs without changing their structure, and therefore extend the half-life of drugs in the human body. The chelating complex micelles contain a metal ion core, at least one polymer, and at least one drug molecule. The metal ion is considered as a Lewis acid while polymer chain and drug molecules are referred to as Lewis bases. The drug molecule is linked to the polymer via forming coordinate bonds with metal ion, and then self-assembled to form chelating complex micelles as a drug carrier.

Chelating complex micelles drug carrier

Pharmaceutical composition of chelating complex micelles

Method of manufacturing a pharmaceutical composition having chelating type complex micelles

Drug carrier with chelating complex micelles and the application thereof

A pharmaceutical polymer and a method for quenching free radicals is described. The pharmaceutical polymer comprises a glycopeptide covalently bound to an aminothiol moiety. The pharmaceutical polymer and method can be applied before or after the occurrence of radiation exposure.

Pharmaceutical compositions

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Kaohsiung, Taiwan

Chau-Hui Wang