Purdue Research Foundation

Charng-yu Lin

Jonathan James Wilker

Julie C Liu

Sydney E Hollingshead

Mary Jane Brennan

This invention relates to protein-based adhesives that are capable to adhere to a substrate in a dry, wet, moist, or an aqueous environment. Particularly, said adhesives comprise a crosslinking agent and an elastin-like polypeptide (ELP) that contain tyrosine, lysine, cysteine, dihydroxyphenylalanine (DOPA) or trihydroxyphenylalanine (TOPA) amino acid residue, or a combination thereof, on the polypeptide chain of said ELP. Among others, the adhesives disclosed herein may find broad applications in medical treatments and surgical operations. Compositions and methods of use are within the scope of this application.

Protein-based adhesive and its modification

Protein-based adhesives. In one embodiment of the present disclosure, an elastin-like polypeptide has a sequence LDGTL-(PGXGVPGKGVPGXGVPGXGVPGXGVPGXGV)-PVADRGMRLE, wherein each Xis selected from the group consisting of tyrosine (Y), dihydroxyphenylalanine (DOPA), and 3,4,5-trihydroxyphenylalanine (TOPA), wherein each Xis selected from the group consisting of valine (V), Y, DOPA, and TOPA, wherein each Xis selected from the group consisting of glutamic acid (E) and lysine (K), and wherein n is at or between 6 and 10 or higher or lower.

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West Lafayette, IN, United States of America

Charng-yu Lin