W. R. Grace Co.

Charles W Simons

Gerald J O'Neill

Robert S Holdsworth

Charles A Billings

Joel A Gribens

Vincent I DiBiasio

Certain fluorinated dimethyl ethers have been found to possess the stability, the compatibility and sufficient freedom from deleterious physiological effects to be used as aerosol propellants in cosmetic, hygienic, pharmaceutical and other personal products. Bis(difluoromethyl) ether is also free of the chlorine atoms believed responsible for some destruction of ozone in the upper atmosphere. Bis(difluoromethyl) ether and carbon dioxide provides a combined gaseous and liquefied propellant system having improved aerosol pattern and emptying characteristics and eliminates the compressed gas effect usually shown by use of carbon dioxide in propellant systems.

Aerosol propellant for personal products

Certain fluorinated dimethyl ethers have been found to possess the stability, the compatibility and sufficient freedom from deleterious physiological effects to be used as aerosol propellants in cosmetic, hygenic, pharmaceutical and other personal products. These compounds, bis(difluoromethyl) ether and perfluorodimethyl ether, are also free of the chlorine atoms believed responsible for some destruction of ozone in the upper atmosphere.

New aerosol propellants for personal products

The following halocyclopropyl halomethyl ethers have been synthesized and found to possess utility as general inhalation anesthetics: 1-chloro-2-chlorofluoromethoxy-1,2,3,3-tetrafluorocyclopropane, 1-chloro-2-difluoromethoxy-1,2,3,3-tetrafluorocyclopropane, 1-bromo-2-chlorofluoromethoxy-1,2,3,3-tetrafluorocyclopropane and 1-bromo-2-difluoromethoxy-1,2,3,3-tetrafluorocyclopropane.

Halocyclopropyl halomethyl ethers

The following chlorocyclopropanes have been found to possess utility as general inhalation anesthetics: 1,1-dichloro-2-methyl-2,3,3-trifluorocyclopropane, 1,2-dichloro-1-fluoro-2-methylcyclopropane, 1,1,2-trichloro-2,3,3-trifluorocyclopropane, 1,1-dichloro-2-trifluoromethyl-2,3,3-trifluorocyclopropane, 1,2-dichloro-1,2,3,3-tetrafluorocyclopropane, 1,1,2,2-tetrachloro-3,3-difluorocyclopropane and 1,1-dichloro-2,3,3-trifluorocyclopropane.

Anesthetic chlorocyclopropanes

The following halogenated cyclobutyl ethers have been found to possess utility as general anesthetics: 1-chloro-2-methoxy-1,2,3,3,4,4-hexafluorocyclobutane, 1-chloro-2-methoxy-1,4,4-trifluorocyclobutane and 1-bromo-2-methoxy-1,2,3,3,4,4-hexafluorocyclobutane.

Halogenated cyclobutyl ether anesthetics

Certain new halogenated cyclobutanes have been synthesized and found to possess utility as inhalation anesthetics. They are: 1,4-dichloro-1,2,2-trifluorocyclobutane, 1-chloro-1,2,2,4-tetrafluorocyclobutane, 1,4-dichloro-1,2,2,4-tetrafluorocyclobutane, 1-chloro-1,2,2,3,3-pentafluorocyclobutane, 1,2,2-trifluorocyclobutane, 1-chloro-2,3,3-trifluorocyclobutane, 1-chloro-2,4 4-trifluorocyclobutane, 1-bromo-1,2,2-trifluorocyclobutane, 1-bromo-2-methyl-1,4,4-trifluorocyclobutane and 1-bromo-2-chloro-1,4,4-trifluorocyclobutane.

New halogenated cyclobutanes

The following halocyclopropyl halomethyl ethers have been synthesized and found to possess utility as general inhalation anesthetics: 1-chloro-2-chlorofluoromethoxy-1,2,3,3-tetrafluorocyclopropane, 1-chloro-2-difluoromethoxy-1,2,3,3-tetrafluorocyclopropane, 1-bromo-2-chlorofluoromethoxy-1,2,3,3-tetrafluorocyclopropane and 1-bromo-2-difluoromethoxy-1, 2,3,3-tetrafluorocyclopropane.

The following newly synthesized bromofluoromethylcyclopropanes have been found to possess utility as general inhalation anesthetics: 1-bromo-1,2-difluoro-2-methylcyclopropane and 1-bromo-1-fluoro-2-methylcyclopropane.

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Bedford, MA, United States of America

Charles W Simons