Institut Pasteur

New York University

Institute Pasteur

Charles W Roth

Faridabano Nato

John W Barnwell

Shirley Longacre-Andre

Kamini Mendis

Thierry Fontaine

Andrey Rzhetsky

Shirley Longacre

Paul T Brey

Inge Holm

Marine Grailles

Sarah Bonnet

The present invention relates to a purified polypeptide comprising or consisting of a C-terminus Merozoite Surface Protein 1 (MSP1) antigen fromcarrying a Glycosyl-phosphatidyl-inositol group (GPI), an immunogenic composition and a vaccine against ainfection comprising said purified polypeptide.

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The invention relates to a recombinant protein fabricated in a baculovirus system, of which the essential constitutive polypeptide sequence is that of a C-terminal fragment of 19 kilodalton (p19) of the surface protein 1 (protein MSP-1) of the merozoite parasite of thetype, particularly, which is infectious for humans, said C-terminal fragment remaining normally anchored at the surface of the parasite at the end of its penetration phase into human erythrocytes, in the occurrence of an infectious cycle. Said recombinant protein is applicable to the production of vaccines against malaria.

The invention provides, inter alia, isolated nucleic acid molecules that comprise nucleic acids encoding multiple drug resistance proteins fromor, herein referred to as dMRP or gMRP, respectively, vectors encoding dMRP or gMRP, and host cells transformed with vectors containing these nucleic acids.

The invention relates to a recombinant protein fabricated in a baculovirus system, of which the essential constitutive polypeptide sequence is that of a C-terminal fragment of 19 kilodalton (p19) of the surface protein 1 (protein MSP-1) of the merozoite parasite of thetype, particularlywhich is infectious for humans, said C-terminal fragment remaining normally anchored at the surface of the parasite at the end of its penetration phase into human erythrocytes, in the occurrence of an infectious cycle. Said recombinant protein is applicable to the production of vaccines against malaria.

Recombinant protein containing a C-terminal fragment of plasmodium MSP-1

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Rueil-Malmaison, France

Charles W Roth