Ici Americas, Inc.

Charles W Perkins

Diane A Trainor

Richard A Wildonger

Philip D Edwards

Joseph J Lewis

The invention provides a series of novel heterocyclic ketones of formula I ##STR1## and pharmaceutically acceptable base-addition salts thereof, in which the values of R.sup.4, L, A, X and Q have the meanings defined in the following specification. The compounds of formula I are inhibitors of human leukocytic elastase. The invention also provides pharmaceutical compositions containing a compound of formula I, or a pharmaceutically acceptable base-addition salt thereof, and processes and intermediates for the manufacture of compounds of formula I.

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Wilmington, DE, United States of America

Charles W Perkins