Columbia University

Uwm Research Foundation, Inc.

Other

Charles W Emala

James M Cook

Douglas C Stafford

Alexander E Arnold

Michael Rajesh Stephen

Guanguan Li

Gloria Forkuo

Rajwana Jahan

Revathi Kodali

Hugh A Sampson

Xiu-Min Li

Nan Yang

Kamal Srivastava

George Gallos

The present invention describes substituted benzo[f]imidazo[1,5-a][1,4]diazepines of the formula (I): wherein R, R, R, R, and X are as disclosed herein. These compounds target alpha-4 and alpha-5 GABAa receptors and are useful for the treatment of airway hyperresponsiveness and inflammation in asthma.

Substituted benzo[f]imidazo[1,5-a][1,4]diazepines as GABA(a) receptor modulators

Substituted benzo[f]imidazo[1,5-&#x3b1;][1,4]diazepines of formula (I') target alpha-4 and alpha-5 GABAreceptors for use in the treatment of airway hyperresponsiveness and inflammation in asthma. Compounds selectively partition to the peripheral compartment and have reduced CNS effects. 

The present invention relates to extracts of, and compounds isolated therefrom for use in modulating airway smooth muscle contractility. Methods of creating enriched extracts ofare disclosed, as are specific compounds isolated therefrom. Methods for the treatment of disorders involving airway smooth muscle, such as asthma, using the compounds and extracts described herein are also disclosed.

Compounds, extracts and methods from chinese medicinal herb sophora flavescens that inhibit airway contraction

Novel methods of treating inflammation and airway constriction using GABAergic compounds with reduced benzo-diazepine-like CNS activity are provided. Novel compounds which selectively target alpha-4 and alpha-5 GABAreceptors and methods of using those compounds to treat bronchoconstriction and inflammation are provided herein.

GABAA agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma

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Woodcliff Lake, NJ, United States of America

Charles W Emala