Novartis Ag

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Charles Voliva

Matthew T Burger

Keith Bruce Pfister

Aaron Matthew Smith

Sabina Pecchi

Allan S Wagman

Simon C Ng

Zhi-Jie Ni

Yanchen Zhang

Sarah Bartulis

Daniel J Poon

Mark Knapp

Paul Andrew Barsanti

Wendy Fantl

Marion Wiesmann

Teresa E Pick

Gordana Babic Atallah

Joelle Verhagen

Kelly Frazier

Hanne Merritt

Thomas Hendrickson

Edwin Iwanowicz

Alicia Louie

Hanne Meritt

Xiahua Xin

Xiaohua Xin

Gordana Ataliah

Aaron Smith

Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases. 

Pyrimidine derivatives used as PI-3 kinase inhibitors

Pyrimidine derivatives used as PI-3-kinase inhibitors

Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases, including proliferative diseases, inflammatory and obstructive airways diseases, allergic conditions, autoimmune and cardiovascular diseases.

PI 3-kinase inhibitors and methods of their use

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Emeryville, CA, United States of America

Charles Voliva