University of Utah Research Foundation

Frontier Scientific, Inc.

Curza Global, LLC

Charles Testa

Glenn D Prestwich

Ryan E Looper

Paul R Sebahar

Jerry Charles Bommer

Travis J Haussener

Carmela Napolitano

Hariprasada R Kanna Reddy

Fabio Maria Sabbatini

Frederick M Hahn

C Dale Poulter

Rita Cornish

Benlsaac C Tresco

Seth Grant

Benisaac C Tresco

The invention is directed to compounds that are active as antibacterial agents. The invention compounds are active against gram-positive and gram-negative bacteria and can be used to treat infections caused by gram-positive and gram-negative bacteria. Also disclosed are processes and intermediates for making the compounds.

Antimicrobial compounds and methods

Described herein are methods and compositions for killing or preventing the growth of microbes. It has been discovered that a class of porphyrins can kill or prevent the growth of microbes. The porphyrins can be used in a number of different applications where microbes grow.

Compositions for killing or preventing the growth of microbes

Topical application of porphyrins for killing or preventing the growth of bacteria or fungi on a mammal

A transgenic bacterial host cell that can be used as a screen for novel antibiotics and herbicides is provided. The genome of the transgenic bacterial host cell comprises disruptions in a first endogenous gene in the MEP pathway) and a transgene that functionally replaces the disrupted first gene. In other embodiments, the genome comprises a disruption in a first endogenous gene in the MEP pathway and a second endogenous gene which is located downstream of the first gene in the MEP pathway. A transgene that functionally replaces the disrupted downstream gene is cloned into the host cell. A mini operon containing the essential genes for the MVA pathway may also be cloned into the host cell. The transgenic host cell may be used in a method for screening compounds for antibiotic and herbicidal properties. The agents determined by the screening method may be used to kill bacteria or plants.

Antibacterial and herbicidal compounds and system for screening the same

Growing community of inventors

Salt Lake City, UT, United States of America

Charles Testa