University of California

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Aurora Biosciences Corporation

The United States of America

The Government of the United States of America

The United States of America As Represented by Nih

Charles S Zuker

Jon Elliot Adler

Mark A Hoon

Ken Mueller

Nick Ryba

Nicholas J P Ryba

Juergen Lindemeier

Jayaram Chandrashekar

Yifeng Zhang

Gregory A Nelson

Greg Nelson

Isolde Erlenbach

Angela L Huang

Aarron Willingham

Richard G Walker

Grace Q Zhao

John D Mendlein

Paul Negulescu

Melvin I Simon

Jon Elliott Adler

Nicholas Jp Ryba

Yumei Sun

Susan Tsunoda

Jimena Sierralta

David M Cowan

Stefan Offermanns

Nicholas JP Ryba

The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptors.

G-protein coupled receptor polypeptides involved in sensory transduction

The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.

Method for identifying compounds that modulate a T2R taste receptor

The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.

Mammalian sweet and amino acid heterodimeric taste receptors comprising T1R3 and T1R1

Nucleic acids encoding T2R bitter taste receptors

The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.

Methods for identifying compounds which modulate T2R bitter taste receptors

Methods for identifying compounds that modulate sensory signaling through the taste cell specific G-protein coupled receptor GPCR-B4

Nucleic acid encoding a T2R taste receptor

The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.

Mammalian sweet taste receptors

Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction

The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled receptor polypeptide, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.

Mammalian T1R3 sweet taste receptors

Methods for identifying modulators of SF taste receptor signaling

The present invention provides, for the first time, nucleic acids encoding a eukaryotic mechanosensory transduction channel (MSC) protein. The proteins encoded by these nucleic acids form channels that can directly detect mechanical stimuli and convert them into electrical signals. These nucleic acids and the proteins they encode can be used as probes for sensory cells in animals, and can be used to diagnose and treat any of a number of human conditions involving inherited, casual, or environmentally-induced loss of mechanosensory transduction activity.

In vitro method for identifying a compound using an eukaryotic mechanosensory transduction channel

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San Diego, CA, United States of America

Charles S Zuker