Merck Sharp + Dohme Corp.

Msd International Gmbh

Charles S Yeung

Phieng Siliphaivanh

Michelle R Machacek

Michael Hale Reutershan

Sebastian Schneider

Shuhei Kawamura

David James Witter

David L Sloman

Craig R Gibeau

Yingchun Ye

Ryan Quiroz

Michael D Altman

Timothy J Henderson

Jean-Laurent Paparin

Houcine Rahali

Chunhui Huang

Sulagna Sanyal

David Annunziato Candito

Steven Mark Silverman

David J Witter

Murray Wan

Jonathan M E Hughes

Patrick S Fier

The present invention provides a compound of Formula (I) (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.

PRMT5 inhibitors

The present invention provides a compound of Formula (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.

The present invention provides a compound of Formula (I) Formula (I) or the pharmaceutically acceptable salts thereof, which are PRMT5 inhibitors.

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Dedham, MA, United States of America

Charles S Yeung