The University of Tennessee Research Foundation

Other

Npi, Llc.

Rxbio, Inc.

Charles Ryan Yates

Duane Douglas Miller

Jordan J Toutounchian

Karin Emmons Thompson

Jayaprakash Pagadala

Renukadevi Patil

Eldon Geisert

Kui Zeng

Shivaputra Appanna Patil

Jena Steinle Smith

Hao Wu

Bob M Moore, Ii

Mahmoud Mirmehrabi

Hector L Lopez

Himanshu Bhattacharjee

Veeresh Gududuru

Pengfei Song

Jonathan Chapman

Ling Lin

Cameron Volpe Fili

Ram Mahato

Gabor Jozsef Tigyi

Jurriaan Strobos

Dick Gourley

Leslie Stuart

Frank Park

Mostafa Waleed Gaber

Vanessa Morales-Tirado

Bilal Abou Aleiwi

Rama Krishna Reddy Singidi

Likeselam Asres

Amira Ahmed

Terreia Jones

Vanessa M Morales-Tirado

Shivaputra Patil

Nutritionally acceptable non-lipid compositions and methods are presented that modulate lipid metabolism, and especially increase LPC concentrations. Consequently, the compositions and methods presented herein will facilitate DHA transport to neural and retinal tissues as well as LA availability for cardiolipin synthesis.

SmartCore compositions and methods

The bird-nesting prevention device is a mechanical structure. The bird-nesting prevention device is configured for use with a porch roof. The porch roof further comprises with a column. The column further comprises with a capital. The capital comprises the elements of the column that attach to the porch roof. The bird-nesting prevention device forms a barrier that prevents one or more birds from nesting on the capital of the column. The bird-nesting prevention device comprises a master prism structure and a bird's mouth cut. The bird's mouth cut is a negative space formed in the master prism structure. The bird's mouth cut attaches the master prism structure to the capital using a bird's mouth joint. The master prism structure forms a barrier that prevents the one or more birds from nesting on the capital of the column.

Bird-nesting prevention device

Here provided are new immunosuppressive compounds and novel therapeutics for improving tissue transplantation.

Immunosuppressive compounds and therapeutics

Here provided is a method for regulating retinal endothelial cell viability in a mammal by administering to the mammal a therapeutically effective amount of a quinic acid analog. The method may be applied to prevent, treat or cure pathological conditions of retinal endothelial cells associated with radiation retinopathy, diabetic retinopathy and chemotherapy for retinoblastoma.

Method for regulating retinal endothelial cell viability

This disclosure relates to small molecule inhibitors of paxillin and paxillin binding, and related compositions and methods of treatment.

Inhibitors of paxillin function and related compositions and methods

Here provided are a salt of Z)&#x2014;O-octadec-9-en-1-yl O,O-dihydrogen phosphorothioate with an L-lysine addition in crystalline form and methods of making and using the same.

Crystalline salts of (Z)-O-octadec-9-en-1-yl O,O-dihydrogen phosphorothioate

Disclosed are compounds for the treatment of cancer. Compounds disclosed herein are particularly effective for the selective inhibition of glioma cells.

Compounds with increased specificity for the treatment of glioma

Disclosed are methods of use of analogs of quinic acids or shikimic acids for protection from the harmful effects of radiation when administered either prior to radiation exposure, after radiation exposure, or both. These methods are useful for treating humans and animals exposed to radiation and at risk for radiation sickness and/or death as the result of radiation exposure.

Anti-inflammatory quinic acid derivatives for radioprotection/radiomitigation

Disclosed are therapeutic tetrahydroisoquinoline compositions for the treatment of cancer, these compositions having selectivity for cancer cells while demonstrating few, if any, deleterious side effects on normal cells.

Therapeutic tetrahydroisoquinoline-based compositions for cancer therapy

Disclosed are compounds comprising analogs of quinic acids or shikimic acids having anti-inflammatory properties. The compounds are suitable for oral administration, stable, and demonstrate significant efficacy in inhibiting NF-kB, inhibiting leukocyte adhesion, and inhibiting other factors and cytokines known to be involved in inflammatory disease.

Anti-inflammatory quinic acid derivatives for oral administration

Cannabinoid derivatives according to formula (I) are disclosed wherein, X, Y, R, R, and W can have the definitions provided herein. Without limitation, use of such compounds, their salts or pro-drug, or compositions containing the compounds, salts, or pro-drug, to modify the activity of CB1 and CB2 receptors and treat conditions mediated by these receptors.

Tri-aryl/heteroaromatic cannabinoids and use thereof

The present invention provides fluorescence-based real-time PCR assays for the rapid detection of single nucleotide polymorphisms (SNPs). The genotyping assay can be used to detect SNPs of a number of genes of interest that include, but are not limited to, the human multidrug resistance gene (MDR1) single nucleotide polymorphisms C3435T and G2677T, and cytochrome P-450 3A5 single nucleotide polymorphisms CYP3A5*3 (A22893G) and CYP3A5*6 (G30597A).

Real-time polymerase chain reaction-based genotyping assay for single nucleotide polymorphism

Growing community of inventors

Collierville, TN, United States of America

Charles Ryan Yates