Sequenom, Inc.

G.d. Searle & Company

Rhodx, Inc.

Charles Rodi

Dirk Johannes Van Den Boom

Andreas Braun

Ping Yip

Liyan He

Norman Chiu

Hubert Köster

Hubert Koster

Christian Jurinke

Dale Lynn Morris

Christiane Jurinke

Roderick T Bunch

Sandra W Curtiss

Provided in certain aspects are methods for dynamically adding molecular indexes to nucleic acid, and optionally analyzing the tagged nucleic acid. Also provided in certain aspects are methods for producing a single-stranded nucleic acid molecule from two molecules. The first molecule typically is a single-stranded nucleic acid (ssNA) containing a target sequence with optional linked nucleic acid sequences. The second molecule typically is a ssNA containing a target binding sequence and a nucleic acid sequence 'tag' that is not complementary to the target sequence. The first and second ssNA molecules can be hybridized or annealed under conditions in which the target sequence and target binding sequence hybridize or anneal to each other by base pair complementarity, followed by contact of the hybridized or annealed molecules with a single-stranded nucleic acid ligase activity that ligates the 3'-end of the first ssNA molecule with the 5&#x2032;phosphate (optionally adenylated) moiety of the second ssNA molecule to produce one product, a ligated ssNA molecule.

Tagging and assessing a target sequence

Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.

Methods for generating databases and databases for identifying polymorphic genetic markers

The present invention relates to carcinogenesis biomarkers produced by phenobarbital-treated rat hepatocytes, nucleic acid molecules that encode carcinogenesis biomarkers or a fragment thereof and nucleic acid molecules that are useful as probes or primers for detecting or inducing carcinogenesis, respectively. The invention also relates to applications of the factor or fragment such as forming antibodies capable of binding the carcinogenesis biomarkers or fragments thereof.

Biomarkers and assays for carcinogenesis

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Del Mar, CA, United States of America

Charles Rodi