University of Florida Research Foundation, Incorporated

California Institute of Technology

Aerovironment, Inc.

Gesellschaft Fuer Schwerionenforschung Mbh

Charles R Martin

Donn Dennis

Nathan S Lewis

Richard Earl Partch

Dinesh Ochhavlal Shah

Timothy E Morey

Manoj Varshney

David T Mitchell

Michael S Freund

Phillip T Tokumaru

Shawn M Briglin

Michael Freund

Reinhard Neumann

Shifeng Hou

Jon Dale Stewart

Christina Trautmann

Richard J Rogers

Zuzanna Siwy

Niels Fertig

Andrzej Fulinski

Eugenia Toimil Molares

Aaron G Wilson

Phil Tokumaru

Juliette Experton

Shawn S Briglin

Jan Behrends

Described herein are systems and methods of flow-through electroporation can comprise a chamber with a first and a second portion, wherein the first portion is configured to receive cells and the second portion is in fluid communication with the first portion and is configured to receive cells from the first portion; an electrode can be present in the first portion, second portion, or both; a porous membrane can separate the first and second portions, the porous membrane can have one or more pores, and the pores can have one or more interior surfaces configured to allow cells from the first portion to pass through to the second portion; an electric generating device in electrical communication with one or more electrodes, the membrane, or the one or more electrodes and the membrane, wherein the electric generating device is configured to deliver constant voltage or one or more electric pulses to the system.

Systems and methods including porous membrane for low-voltage continuous cell electroporation

A method of forming DNA nanotubes composed entirely or predominantly from DNA that, The methods of the present invention form single layer or multilayer template-synthesized nanotubes where the bulk of the tube is composed of DNA, and the layers are held together by hybridization of complementary DNA strands. The DNA molecules making up these tubes may be varied as desired, and the DNA is capable of being released from the tube.

Template-synthesized DNA nanotubes

The present invention relates to an apparatus having a nanodevice () for controlling the flow of charged particles in an electrolyte. Such apparatus comprises an electrolytic bath container () divided by a polymeric membrane foil () into a first () and a second compartment (), wherein each compartment () comprises an electrode () connected to a voltage supply (). Further the apparatus comprises at least one asymmetric pore () forming a via hole through said foil (), wherein said pore () provides a narrow opening () of a diameter in the range of several nanometers down to about one nanometer on a front side () of said foil () and a wide opening () in the range of several ten nanometers up to several hundred nanometers on a back side () of said foil (). Further, the apparatus comprises an electrically conductive layer () surrounding said narrow opening () on said front side () and a gate voltage supply () connected to said electrically conductive layer () on said front side () of said foil () controlling the flow of charged particles within said nanodevice () from said first compartment () to said second compartment () vice versa. The invention further relates to a method for producing such a nanodevice ().

Nanodevice for controlled charged particle flow and method for producing same

Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one or more surfaces relative to one or more fluid channels in an array. Fluid channels can take the form of pores or holes in a substrate material. Fluid channels can be formed between one or more substrate plates. Sensor can be fabricated with substantially optimized sensor volumes to generate a response having a substantially maximized signal to noise ratio upon introduction of a fluid containing one or more target analytes. Methods of fabricating and using such sensor arrays and systems are also disclosed.

Spatiotemporal and geometric optimization of sensor arrays for detecting analytes in fluids

A method of removing a toxic compound comprising contacting the toxic compound with a particle having two regions, the first region containing a detoxifying enzyme and the second region containing a material selected to partition the toxic compound into the second region. The particle may be a nanoparticle.

Detoxification and decontamination using nanotechnology therapy

The invention relates to the nanotubes of various sizes and composed of a wide variety of materials, or combination of materials. The invention also describes the use of such nanotubes for the delivery of various payloads and, in particular, for the in vivo delivery of bioactive substances.

Nanoparticle delivery system

Spatiotemporal and geometric optimization of sensor arrays for detecting analytes fluids

A particle with two regions, the first region contains a detoxifying enzyme and a second region that partitions toxic compounds. The particle may be a nanoparticle.

Growing community of inventors

Gainesville, FL, United States of America

Charles R Martin