The UAB Research Foundation (The University of Alabama at Birmingham)

Cedars-sinai Medical Center

Charles O Elson

Stephan R Targan

Jerome I Rotter

Kent D Taylor

Yingzi Cong

Wayne Duck

Qing Zhao

Katie Alexander

Provided herein are methods and compositions for treating and preventing inflammatory bowel disease.

Immunotherapy for the treatment and prevention of inflammatory bowel disease

This invention provides methods of diagnosing or predicting susceptibility to Crohn's Disease by determining the presence or absence of genetic variants. In one embodiment, the present invention provides methods to diagnose and/or predict susceptibility to Crohn's Disease in an individual by determining the presence or absence of anti-Cbir1 reactivity and the presence or absence of TLR5 risk variants. In another embodiment, the present invention provides methods to diagnose Crohn's Disease by determining the presence or absence of NFKB1 haplotype H3 and/or ASCA expression. In another embodiment, the present invention provides methods of diagnosing Crohn's Disease by determining the presence or absence of Cbir1 specific peripheral blood T cell proliferation.

Characterization of the CBir1 antigenic response for diagnosis and treatment of Crohn's disease

Compositions and methods for the therapy and diagnosis of immune-mediated inflammatory diseases, including inflammatory bowel disease (IBD), Crohn's disease and ulcerative colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention or treatment of immune-mediated inflammatory disease.

Compositions and methods for the identification and treatment of immune-mediated inflammatory diseases

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Birmingham, AL, United States of America

Charles O Elson