Other

Centre National De La Recherche Scientifique

Commissariat a L'energie Atomique

Pierre Fabre Medicament

Université Louis Pasteur

Rhodia Chimie

Ucb S.a.

Aventis Cropscience S.a.

Rhone-poulenc Agro

Université Louis Pasteur Strasbourg I

Charles Mioskowski

Alain Wagner

Marc Nicolas

Patrick Schultz

Rachid Baati

Marc Schmutz

Rachel Decor

Jean-Paul Lellouche

Vanessa Gonnot

Virginie Pevere

Luc Quere

Fabrice Balavoine

Patrice Talaga

Jean-Philippe Starck

Matteo Zanda

Cédric Catala

Sandra De Lamo Marin

Cedric Catala

Jean-Michel Becht

Michel Guyaux

Chimmanamada U Dinesh

Michio Ishibashi

Catherine Sylvain

Arnaud Gissot

Thierry Le Gall

Jean Roger Desmurs

Jean-Philippe Goddard

Levannier Karine

Stéphane Rickling

Karine Levannier

The invention relates to a 1-aza-bicyclo[2.2.2]oct-2-en-3-ylmethyl acetate of the formula (I), wherein said compound is useful as a synthesis intermediate for the production of mequitazine.

Quinuclidine derivative useful in the preparation of mequitazine

The invention relates to polymers comprising a sequence of units comprising an ethylenic unsaturation, the unsaturation being located every 3 carbon atoms between two successive units. The invention also relates to processes for preparing such polymers.

Polymers comprising in their skeleton an endo ethylenic unsaturation, and preparation processes therefor

The invention relates to macromolecules auto-assembled and photopolymerised around carbon nanotubes. Said macromolecules are essentially formed from rings of lipid compounds, polymerised about the nanotubes, said polymerised compounds being obtained from lipid molecules with one or two chains A, bonded to a group Z where A is a chain, CH&#x2014;(CH)&#x2014;C&#x2261;C&#x2014;C&#x2261;C&#x2014;(CH)&#x2014;, where n and m, independently=whole numbers from 1 to 16 and Z is a polar head group embodied by a &#x2014;COOH, &#x2014;CO&#x2014;NH&#x2014;Y, &#x2014;NHor N(R), where R is an alkyl with C, to Cand Y is a &#x2014;(CH)&#x2014;C(R)&#x2014;N(CH&#x2014;COOH)group with R=H, or a COOH group, where A is a single lipid chain or a group of structure (I) or (II), where R2=a COOH, or &#x2014;CO&#x2014;NH&#x2014;Ygroup with Y=a &#x2014;(CH)&#x2014;C (R)&#x2014;N(CHCOOH)group with R=H or a COOH group, where Z and Rcan also be neutral polar head groups of the sugar or polysaccharide type. The above is of application particularly to the protection and purification of nanotubes, as a hydrophobic molecule or membrane protein vector or as a molecular motor.

Macromolecules auto-assembled and photopolymerised around carbon nanotubes, a method for production and application thereof

The invention concerns a method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof of general formula (I), characterized in that it consists in reducing an isoxazole derivative of formula (II) in conditions directly resulting in the derivatives of formula (I), or in obtaining at least a lactone of structure (III) in racemic form(s), or a enantiomerically enriched mixture, followed by opening, in basic conditions, in an aprotic or protic solvent, the desired lactone(s) and, optionally, separating the desired form. The invention is useful for preparing in particular (2S, 3R, 4S)-4-hydroxyisoleucine.

Method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof

The invention concerns quinuclidine derivatives of formula I or II wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the invention show high affinities for m3 and/or m2 muscarinic receptors and are particularly suited for treating urinary incontinence.

Quinuclidine derivatives processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors

The invention relates to a method for the synthesis of two isomers, at function OH, alone or in mixtures, of amino acids &#x3b1; or the derivatives thereof, having general formula (B), wherein: linkage C&#x2014;O of the 4-position carbon (represented by symbol) denotes one or other of isomers III or IV, or mixtures thereof. Moreover, Rand Rrepresent: a hydrogen atom; or either Ror Rrepresents a hydrogen atom and the other substituent is a radical R, an acyl group &#x2014;COR, such as acetyl, or a functional group &#x2014;COOR, &#x2014;SOR, &#x2014;N (R, R), Rand R, which are identical or different, representing a C1-C12 linear or branched alkyl radical, optionally substituted, an aryl group with one or more aromatic rings and heterocycles, comprising between 5 and 8C, optionally substituted, or aralkyl, the alkyl substituent and the aryl group being as defined above; or Rand Rboth represent a substituent as defined above. Rrepresents a hydrogen atom or Rand Rhas the significance of R. The invention is characterised in that it comprises: the isomerisation of a compound having formula (I), wherein R, R, R, Rand Rare as defined above, such as to produce a compound having formula (II); and the reduction of the carbonyl function thereof which, depending on the catalytic system employed and the formula (I) compound used, produces one of the isomers having general formula (III) or (IV) or a mixture thereof having formula (B). The invention can be used for the synthesis of (2S, 3R, 4S)-4-hydroxyisoleucine.

Method for the synthesis of 4-hydroxyisoleucine and the derivatives thereof

Drugs for preventing and/or treating progressive lesions after organ damage without inhibiting the function of the organ or the regeneration function thereof, by selectively regulating the induction of cytotoxic effecter macrophages which are induced into damaged organ tissues in response to chemokines or cytokines expressed depending on the type of the damaged organ tissues.

Selective preventives/remedies for progressive lesions after organ damage

The invention concerns molecular rods, their uses in a method for fixing and/or crystallising macromolecules, the resulting products and uses of said products in the field of materials and structural biology, in particular as biosensors or as biomaterials. Said molecular rods have a structure represented by the general formula (I) and said method essentially consists in incubating, for at least 15 minutes, a biological macromolecule in solution with a molecular rod as defined by the formula, in suitable temperature and pH conditions.

Molecular rod and uses

The invention concerns a method for orthometalation of a carbocyclic aromatic derivative bearing at least an electron donor group, characterised in that it consists in reacting said carbocyclic aromatic derivative with an efficient amount of at least one alkaline metal in the presence of a compound of formula (I): RX, wherein: R represents a hydrocarbon radical having 1 to 20 carbon atoms which can be a saturated or unsaturated, linear or branched, acyclic aliphatic radical; a saturated or unsaturated, monocyclic or polycyclic cycloaliphatic radical; a saturated or unsaturated, linear or branched aliphatic radical bearing a cyclic substituent; and X represents a bromine or chlorine atom.

Method for orthometalation of a carbocyclic aromatic derivative bearing at least an electron donor group

The present invention relates to a method of transforming cells in which an appropriate quantity of nucleic acid fragments is introduced into the cells. The nucleic acid fragments are introduced in the form of a nucleic acid composition comprising a nitrogen-containing silicone, useful for compacting the nucleic acid fragments; the compositions comprise aggregates of nucleic acid fragments and silicones according to the invention.

Nitrogen-containing silicone useful for compacting nucleic acid sequences and use for transforming cells

Nitrogen-containing silicone useful for compacting nucleic acid

The invention relates to a process for the synthesis of an acylated derivative of a fatty acid-transporting thiol such as the coenzyme A. According to this process, a silylated or stannylated thiol is prepared by reacting the thiol with a silylation or stannylation reagent in order to at least partly replace the unstable hydrogens of the thiol by SiR.sub.3 or SnR.sub.3 groups with R being an alkyl or aryl group. The silylated or stannylated thiol is then reacted in an anhydrous organic medium with an activated organic acid and a deprotection reagent able to eliminate the silyl or stannyl groups. In this way it is possible to obtain acylated derivatives of the coenzyme A, in which the acyl group can have up to 30 carbon atoms with high yields.

Process for the synthesis of acylated derivatives of fatty

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Strasbourg, France

Charles Mioskowski