Grifols Worldwide Operations Limited

Grifols, S.a.

Grifols Therapeutics Inc.

Charles Miller

Thomas P Zimmerman

James Rebbeor

Jennifer Audrey Hunt

Anthony Klos

Eric Allgaier

Kevin Wee

Michelle StPeter

Kelly Glancy

David Ownby

Senthil Ranganathan

Tonny Dessources

Edward Koepf

Myles Lindsay

Rebecca Silverstein

Anthony Caronna

Kenya Stokes

Compositions include highly concentrated Alpha-1 Proteinase Inhibitor (A1PI) in a concentration greater than or equal to 100 mg/ml. Pharmaceutical compositions can be prepared from these compositions. The pharmaceutical compositions can be suitable for subcutaneous administration. The highly concentrated A1PI solutions can be obtained by single-pass tangential flow filtration (SPTFF).

Composition comprising highly-concentrated Alpha1 proteinase inhibitor and method for obtaining thereof

Compositions include highly-concentrated Alpha-1 Proteinase Inhibitor (A1PI) in a concentration greater than or equal to 100 mg/ml. Pharmaceutical compositions can be prepared from these compositions. The pharmaceutical compositions can be suitable for subcutaneous administration. The highly-concentrated A1PI solutions can be obtained by single-pass tangential flow filtration (SPTFF).

Composition comprising highly-concentrated &#x3b1;1 proteinase inhibitor and method for obtaining thereof

Composition comprising highly-concentrated ALPHA1 proteinase inhibitor and method for obtaining thereof

Described herein are methods for purifying recombinant, cell culture derived alpha-protease inhibitor and removing a colored species that co-purifies with the recA1PI protein. Also described are methods for reducing the iron in cell culture derived alpha-protease inhibitor.

Purification of cell culture derived alpha1 protease inhibitor

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Compositions and methods for preparing plasminogen, in particular recombinant plasminogen, and compositions and methods of utilizing same for preparing plasmin are provided.

Compositions, methods and kits for preparing plasminogen and plasmin prepared therefrom

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Apex, NC, United States of America

Charles Miller