Ciba-geigy Corporation

Charles Meystre

Georg Anner

Hansuli Wehrli

Adrian Marxer

The derivatives of 1-dehydro-6.alpha.,9.alpha.-difluoro-16.alpha.-methyl-corticosterone having an aldehyde group in 21-position instead of the hydroxyl group, and derivatives of such aldehydes having a 2-chlorine atom, the corresponding hydrates, as well as their functional aldehyde derivatives, such as the acetals, display an antiinflammatory and thymolytic action. They are prepared by conventional methods.

Aldehydes of the pregnane series and derivatives thereof

Compounds of the general formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a lower alkyl group, which contain a double bond in 5-position and a methyl group in 10-position, or three double bonds in the position 1,3 and 5)10), and which can contain an additional double bond in the 9(11)-position, are manufactured by a novel process, in which a 17-oxosteroid of the general formula ##STR2## wherein R.sub.1 ' represents a hydrogen atom, a lower alkyl group or an acyl group, and which contains double bonds and optionally a methyl group in the positions indicated above, is reacted with an organometallic compound of the formula

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Reinach, Switzerland

Charles Meystre