Kalypsys, Inc.

Charles Maxwell Lawrence

James W Malecha

Stewart Alwyn Noble

Timothy Z Hoffman

Christian Andreus Hassig

Paul L Wash

Brandon M Wiley

Disclosed herein are carbonyl compounds of Formula I as described herein.  Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.

Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease

Disclosed herein are carbonyl compounds of having the structural formula:  Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.

Sulfonamides as inhibitors of histone deacetylase for the treatment of disease

Growing community of inventors

San Diego, CA, United States of America

Charles Maxwell Lawrence