Genentech, Inc.

Novartis Ag

Other

Charles M Winter

Henry Bernard Lowman

Robert F Kelley

Menno Van Lookeren Campagne

Arthur Huang

Arthur J Huang

The present disclosure provides a process for concentrating proteins including an ultrafiltering, a diafiltering, and a second ultrafiltering sequence, at elevated temperatures, such as above about 30° C. The disclosure also includes a process for preparing highly concentrated antibody compositions, and highly concentrated antibody products.

Process for concentration of antibodies and therapeutic products thereof

This present disclosure provides a process for concentrating proteins including an ultrafiltering, a diafiltering, and a second ultrafiltering sequence, at elevated temperatures, such as above about 30&#xb0; C. The disclosure also includes a process of preparing highly concentrated antibody compositions. and highly concentrated antibody products.

The present disclosure provides a process for concentrating proteins including an ultrafiltering, a diafiltering, and a second ultrafiltering sequence, at elevated temperatures, such as above about 30&#xb0; C. The disclosure also includes a process for preparing highly concentrated antibody compositions, and highly concentrated antibody products.

The invention relates to anti-Factor D antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.

Humanized anti-factor D antibodies and uses thereof

Polynucleotides encoding humanized anti-factor D antibodies

A truck having a deck unit pivotally connected to the rearward end of a truck chassis rearwardly of the rear wheels, expansible power mechanism connected to the forward end of the deck unit and operable to elevate it to dispose the unit at an acute angle to the horizontal for loading a vehicle onto the deck unit when the rearward end thereof is substantially in engagement with a pavement surface or the like; the improvement comprising a latch mechanism pivotally connected at one end to the deck unit and the other end pivotally interconnectible to the rear wheels, whereby as the power mechanism is expanded to tilt the deck unit as above described, continued expansion operates to compress the conventional springs by which the rear wheels are connected to the chassis and thereby lowers the rearward end of the chassis and, accordingly, lowers the pivot which connects the deck unit to the rear end of the chassis and thereby further decreases the acute angle of the deck unit to the horizontal to facilitate loading vehicles onto the deck unit without interference of the overhanging ends of the vehicle with the surface of the deck unit.

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Belmont, CA, United States of America

Charles M Winter