Agios Pharmaceuticals, Inc.

Charles Kung

Zhihua Sui

Tao Liu

Giovanni Cianchetta

Zhenwei Cai

Dawei Cui

Anil Kumar Padyana

Jingjing Ji

Samuel V Agresta

Lenny Dang

Hua Yang

Bruce A Silver

Leonard Luan C Dang

Marvin Barry Cohen

Elizabeth A Merica

Yue Chen

Marvin B Cohen

Bruce Alan Silver

Leonard Luan Dang

Described herein are methods of using compounds of Formula (I) to modulate PKM2 activity in a subject. These compounds are represented by Formula (I): wherein R, R, L, and Lare as defined herein.

Pyruvate kinase modulators and use thereof

Described herein are methods of using compounds of Formula (I) to modulate PKM2 activity in a subject. These compounds are represented by Formula (I): wherein R, R, L, and Lare as defined herein. 

Described herein are methods for using compounds that activate pyruvate kinase.

Methods of using pyruvate kinase activators

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Arlington, MA, United States of America

Charles Kung