Ironwood Pharmaceuticals, Inc.

Charles Kim

Joel D Moore

Takashi Nakai

Ara Mermerian

Nicholas Robert Perl

Jason Matthew Rohde

Rajesh R Iyengar

Angelika Fretzen

Kevin Sprott

Timothy Claude Barden

Thomas Wai-Ho Lee

John Jeffrey Talley

Mark G Currie

G Todd Milne

James Philip Pearson

Jane Yang

Wilmin Bartolini

Paul A Renhowe

Craig N Zimmerman

Barbara B Chen

Brian Cali

G-Yoon Jamie Im

Colleen Hudson

Daniel P Zimmer

James Jia

Yueh-Tyng Chien

Wayne Schairer

Bo Peng

Regina Lundrigan

Regina Graul

Regina Lundigran

Paul Allan Renhowe

Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed. 

SGC stimulators

Compound of Table I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.

2-benzyl, 3-(pyrimidin-2-yl) substituted pyrazoles useful as sGC stimulators

Compounds of Formula IA and Formula IB are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed. 

sGC stimulators

Indole derivatives that are useful for treating pain, inflammation and other conditions are described. Certain of the compounds are benzyl derivatives and others are benzoyl derivatives. The compounds are substituted at least at the 3 position of the indole.

Indole compounds

Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I: 

CRTH2 modulators

Indoles that have activity as inhibitors of FAAH are described as are indoles and indole derivatives that have activity as inhibitors of DAO.

Useful indole compounds

Growing community of inventors

Cambridge, MA, United States of America

Charles Kim