Tyndale Plains-hunter, Ltd.

National Patent Development Co.

Hymedix International, Inc.

Charles K Kliment

George E Seems

Vladimir A Stoy

Francis E Gould

The present invention is directed to a composition comprising a nitrogen-containig drug-polymer salt and a method for making said composition. The drug-polymer salt is comprised of one or more drugs having basic groups as part of their chemical structure which are capable of forming salts with acids and one or more hydrophilic polymers containing carboxylate groups and amidine groups as pendant groups. Such polymeric salts of drugs have been found to have excellent bio-availability and advantageous release profiles in various forms (gels, ointments, pills, etc.). Particularly advantageous polymers contain pendant nitrile groups in addition to carboxyls and amidines which provide the polymer with hydrogel characteristics.

Polymeric nitrogen-containing drug salt forms for controlled release

The coefficient of friction of surfaces of articles, wherein the surface comprises a hydrophilic polyurethane polymer, is reduced by treating the surface with a mixture of concentrated sulfuric acid and a low molecular weight organic polyhydroxy compound, and removing excess treating mixture. Typical low friction articles produced thereby are boat hulls having drag resistant coatings, conduits having low friction linings, and cannula or body implants having slippery surfaces.

Articles having low friction surfaces and production thereof

An article having a lower coefficient of friction in the wet state is produced by applying to a substrate an adherent isocyanate coating followed by a second coating of polyvinylpyrrolidone copolymerized with a minor amount of an ethylenic monomer having active hydrogens and curing the so-coated substrate to effect reaction between the active hydrogens and isocyanate groups. The article is useful in the manufacture of medical devices for insertion in the body.

Hydrophilic coating and substrate coated therewith

A copolymer of at least one hydroxy (lower alkyl) 2-alkenoate, e.g., hydroxyethyl methacrylate, with 35 to 80%, preferably 50 to 80%, of at least one diester of an alkenedioic acid in hydrogel form is employed to entrap flavors and fragrances in an amount of 5 to 80% or even up to 90%, preferably 30 to 80% of the total formulation. A solvent can also be present in an amount up to 80%, preferably 10-80% of the total weight of the formulation.

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Princeton, NJ, United States of America

Charles K Kliment