Other

Sri International

Large Scale Biology Corporation

Charles K Hiebert

Nahid S Waleh

Keith R Laderoute

Daniel Tuse

Kenneth J Ryan

Cris M Olsen

Alan Laibelman

A Merrill Knapp

Daniel Tus{acute Over (e)}

Xiaoying Chen

The present invention relates to methods for effectively inhibiting inflammatory diseases, such as Crohn's disease and ulcerative colitis. In other aspects, this invention relates to methods of reducing or inhibiting granulomas.

Method for inhibiting inflammatory disease

The present invention relates, inter alia, to compounds that bind tubulin and exhibit anti-mitotic properties and to methods of using such compounds to inhibit abnormal cell mitosis and, in particular, to inhibit tumor cell growth. In addition, methods are presented of treating mammalian diseases associated with undesired and uncontrolled angiogenesis.

Di-aryl ethers and their derivatives as anti-cancer agents

The present invention relates to methods for effectively inhibiting unwanted angiogenesis. More particularly, this invention relates to methods of treating diseases that show unwanted angiogenesis and to delivering anti-angiogenic activity to a mammal. In other aspects this invention relates to methods of reducing the level of tumor necrosis factor .alpha..

Methods for inhibiting angiogenesis

Novel therapeutic agents useful as inhibitors of HLE are provided. The compounds have the structural formula (I) ##STR1## wherein R.sup.1 through R.sup.9, m, n and p are as defined herein. Methods of using the compounds of formula (I) to inhibit serine proteases and to treat physiological conditions and disease states associated with elevated HLE levels are also provided, as are pharmaceutical compositions containing the compounds.

Human leukocyte elastase (HLE) inhibitors, and related pharmaceutical

Growing community of inventors

Sunnyvale, CA, United States of America

Charles K Hiebert