The University of New Mexico

Other

National Technology & Engineering Solutions of Sandia, LLC

Gas Research Institute

Sandia National Laboratories

Sandia Natl Laboratories

Charles Jeffrey Brinker

Hongyou Fan

David Jerrel Kissel

Gabriel P Lopez

Yunfeng Lu

Narayan K Raman

Dhaval Doshi

Nicola Huesing

Alan Hurd

Paul N Durfee

Thomas W Bein

Gregory C Frye

Xingmao Jiang

Kimberly Butler

Rakesh Sehgal

Sai Sivasankaran Prakash

Yu-Shen Lin

Hon Leong

Kelly D Brown

The present disclosure is directed to protocells or nanoparticles, which are optionally coated with a lipid bilayer, which can be used for targeting bone tissue for the delivery of bioactive agents useful in the treatment and/or diagnosis of bone cancer, often metastatic bone cancer which often occurs secondary to a primary cancer such as prostate cancer, breast cancer, lung cancer and ovarian cancer, among numerous others. These protocells or nanoparticles target bone cancer especially metastatic bone cancer with bioactive agents including anticancer agents and/or diagnostic agents for purposes of treating, diagnosing and/or monitoring the therapy of the bone cancer. Osteotropic protocells or nanoparticles, pharmaceutical compositions comprising a population of osteotropic protocells or nanoparticles and methods of diagnosing, treating and/or monitoring therapy of bone cancer are representative aspects.

Osteotropic nanoparticles for prevention or treatment of bone metastases

In one aspect, the disclosure provides mesoporous silica nanoparticles (MSNPs), monodisperse populations of MSNPs and related protocells which exhibit cell binding specificity. For example, MSNPs and protocells of the disclosure may be used to target specific delivery of therapeutic agents to CD19 or EGFR expressing cancer cells, or target specific delivery of therapeutic agents to other cell types. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.

Active targeting of cells by monosized protocells

Provided are polymer-aerogel composite coatings, devices and articles including polymer-aerogel composite coatings, and methods for preparing the polymer-aerogel composite. The exemplary article can include a surface, wherein the surface includes at least one region and a polymer-aerogel composite coating disposed over the at least one region, wherein the polymer-aerogel composite coating has a water contact angle of at least about 140&#xb0; and a contact angle hysteresis of less than about 1&#xb0;. The polymer-aerogel composite coating can include a polymer and an ultra high water content catalyzed polysilicate aerogel, the polysilicate aerogel including a three dimensional network of silica particles having surface functional groups derivatized with a silylating agent and a plurality of pores.

Durable polymer-aerogel based superhydrophobic coatings: a composite material

Provided are superhydrophobic coatings, devices and articles including superhydrophobic coatings, and methods for preparing the superhydrophobic coatings. The exemplary superhydrophobic device can include a substrate component and one or more superhydrophobic coatings disposed over the substrate component, wherein at least one of the one or more superhydrophobic coatings has a water contact angle of at least about 150&#xb0; and a contact angle hysteresis of less than about 1&#xb0;. The one or more superhydrophobic coatings can include an ultra high water content acid catalyzed polysilicate gel, the polysilicate gel including a three dimensional network of silica particles having surface functional groups derivatized with a silylating agent and a plurality of pores.

Superhydrophobic aerogel that does not require per-fluoro compounds or contain any fluorine

Durable polymer-aerogel based superhydrophobic coatings, a composite material

In accordance with invention, there are methods for fabricating hollow spheres and nanofoams. The method for making hollow spheres can include providing a homogeneous precursor solution including a first solvent and one or more anhydrous precursor species and forming aerosol droplets having a first size distribution using the homogeneous precursor solution in an anhydrous carrier gas. The method can also include transporting the aerosol droplets through an aerosol reactor including a reactant to form a plurality of hollow spheres, wherein each of the plurality of hollow spheres can be formed by one or more chemical reactions occurring at a surface of the aerosol droplet. The method can further include controlling size and thickness of the hollow spheres by one or more of the precursor solution concentration, aerosol droplet size, temperature, residence time of the aerosol droplets in the aerosol reactor, and the reactant distribution in the aerosol reactor.

Hollow sphere metal oxides

The present invention provides a mesoporous material comprising at least one region of mesoporous material patterned at a lithographic scale. The present invention also provides a method for forming a patterned mesoporous material comprising: coating a sol on a substrate to form a film, the sol comprising: at least one photoactivator generator, at least one material capable of being sol-gel processed; and exposing the film to light to form a patterned mesoporous material.

Photo-definable self-assembled materials

The present invention provides a coating composition comprising: A coating composition comprising: TEOS; a surfactant; at least one organosilane; HCl; water; and ethanol. The present invention also provides films made from such a coating composition and a method for making such films.

Prototyping of patterned functional nanostructures

The present invention provides a mesoporous material comprising at least one region of mesoporous material patterned at a lithographic scale. The present invention also provides a a method for forming a patterned mesoporous material comprising: coating a sol on a substrate to form a film, the sol comprising: a templating molecule, a photoactivator generator, a material capable of being sol-gel processed, water, and a solvent; and exposing the film to light to form a patterned mesoporous material.

A method for preparing aerogel thin films by an ambient-pressure, continuous process. The method of this invention obviates the use of an autoclave and is amenable to the formation of thin films by operations such as dip coating. The method is less energy intensive and less dangerous than conventional supercritical aerogel processing techniques.

Ambient pressure process for preparing aerogel thin films reliquified

A process for producing a molecular sieve silica membrane comprising depositing a hybrid organic-inorganic polymer comprising at least one organic constituent and at least one inorganic constituent on a porous substrate material and removing at least a portion of the at least one organic constituent of the hybrid organic-inorganic polymer, forming a porous film.

Molecular sieving silica membrane fabrication process

Supported inorganic membranes capable of molecular sieving, and methods for their production, are provided. The subject membranes exhibit high flux and high selectivity. The subject membranes are substantially defect free and less than about 100 nm thick. The pores of the subject membranes have an average critical pore radius of less than about 5 .ANG., and have a narrow pore size distribution. The subject membranes are prepared by coating a porous substrate with a polymeric sol, preferably under conditions of low relative pressure of the liquid constituents of the sol. The coated substrate is dried and calcined to produce the subject supported membrane. Also provided are methods of derivatizing the surface of supported inorganic membranes with metal alkoxides. The subject membranes find use in a variety of applications, such as the separation of constituents of gaseous streams, as catalysts and catalyst supports, and the like.

Growing community of inventors

Albuquerque, NM, United States of America

Charles Jeffrey Brinker