Johns Hopkins University

Charles J Lowenstein

Craig N Morrell

Solomon H Snyder

Arthur L Burnett

David S Bredt

Kenji Matsushita

Thomas S Chang

The present invention relates to methods and compositions for modulating platelet activity by inhibiting or activating glutamate receptors. The invention further relates to preventing or treating thrombotic diseases.

Glutamate receptor antagonists and methods of use

Methods and compositions for blocking exocytosis by inhibition of proteins that regulate exocytosis, such as N-ethylmaleimide Sensitive Factor (NSF), are provided. The compositions include multidomain fusion peptides containing a domain that causes the fusion peptide to cross the cellular membrane (e.g. a domain from the TAT protein of HIV) and a domain that inhibits NSF (e.g. a domain of NSF). Administration of the fusion peptide promotes anticoagulation, attenuates thrombosis, and decreases heart attack severity.

Inhibitors of N-ethylmaleimide sensitive factor

Methods and devices are taught for regulating penile erection and urethral function. Inhibitors of nitric oxide synthase and precursors of nitric oxide are applied to relax or contract the muscles of the corpus cavernosum and the urethra.

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Pittsford, NY, United States of America

Charles J Lowenstein