Queen's University at Kingston

Cellegy Pharmaceuticals Inc.

Charles H Graham

Michael A Adams

Jeremy P W Heaton

Lynne-Marie Postovit

Susan E Brien

Lynn-Marie Postovit

The present invention relates to methods and formulations for inhibiting, treating and preventing a malignant cell phenotype, cell, tumor and/or disease. Administration of nitric oxide mimetics, such as low doses, is sufficient to increase, restore or maintain nitric oxide-mediated signaling in cells so that malignant cell phenotypes, cells, tumors and/or diseases are inhibited or prevented. These methods and formulations are particularly useful in treating and preventing cancer in animals.

Formulations and methods of using nitric oxide mimetics in cancer treatment

Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype

Methods and formulations for inhibiting and preventing a malignant cell phenotype by administering to cells a low dose of a nitric oxide mimetic are provided.

A method for diagnosing hypoxia, endothelial dysfunction, a vascular or circulatory condition of a subject, in which the level of expression of a gene, and/or the level of a metabolite or metabolic by-product in a biological test sample is measured and compared to a control sample so as to assess the vascular condition of the subject, is described.

Growing community of inventors

Kingston, Canada

Charles H Graham