Mbio Diagnostics, Inc.

Accelr8 Technology Corporation

Charles Greef

Michael J Lochhead

Guoqiang Mao

David A Goldberg

Steven W Metzger

Keagan B Rowley

Kurt Richard Vogel

Kevin D Moll

Marie J Delaney

Jeffrey T Ives

Christopher J Myatt

Daniel T Nieuwlandt

John S Dunn

Kathryn Todorof

Evelyn S Woodruff

David W Grainger

A rapid diagnostic system that delivers a panel of serologic assay results using a small amount of blood, serum, or plasma is described. The system includes a disposable cartridge and a reader instrument, based on planar waveguide imaging technology. The cartridge incorporates a microarray of recombinant antigens and antibody controls in a fluidic channel, providing multiple parallel fluorescence assay results for a single sample.

System and method for detecting multiple molecules in one assay

Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.

Hydroxyl functional surface coating

Growing community of inventors

Louisville, CO, United States of America

Charles Greef