Novabay Pharmaceuticals, Inc.

Pfizer Corporation

Novartis Ag

Vicuron Pharmaceuticals Inc.

Vicuron Holdings LLC

Gottardi, Waldemar

Nagl, Markus

Charles Francavilla

Rakesh K Jain

Timothy Shiau

Eddy Low

Eric Douglas Turtle

Donogh John Roger O'Mahony

Mohindra Seepersaud

Lei Shu

Zhengyu Yuan

Simon Bushell

Arathi Sundaram

Satheesh K Nair

Kathryn Rene Bracken

Karl Dean

Kwangho Lee

Jason Gustaf Lewis

Mikhail Fedorovich Gordeev

Ramin Najafi

Bum Kim

David Stroman

Markus Nagl

Lu Wang

Timothy P Shiau

Arathia Sundaram

The present invention relates generally to systems and methods for cleaning and disinfecting contact lenses. In various respects, the invention is directed to an insulated system that reduces heat loss from catalyzed neutralization of a disinfecting solution resulting in an increased temperature of the disinfection solution during the disinfection process and neutralization of the disinfection solution. The increased temperature increases the kill rate (i.e., better reduction) of microorganisms present on the lenses, and increases the neutralization rate of the disinfection solution. Increase of the kill rate allows better reduction of microorganisms resistant to elimination using previous systems and methods, (e.g.,cysts), and decreases the amount of time as compared to previous systems and methods necessary to reduce microorganisms to acceptable levels.

Contact lens cleaning system with insulation

The present application describes compounds of Formula I: which are antimicrobial agents, including antibacterial, disinfectant, antifungal, germicidal and/or antiviral agents.

Substituted N,N-dihaloamines as antimicrobials

The invention monitors the neutralization process involving hydrogen peroxide solution and a hydrogen peroxide neutralization catalyst and compares measured values with theoretical values. The system monitors the chemical reaction and notifies the user of the neutralization status. In an exemplary embodiment, the initial hydrogen peroxide solution concentration is neutralized with a palladium catalyst after a period of time. A microcontroller analyzes the measurements and displays the neutralization process results using colored LED lights and/or text or images on a LCD display. In one embodiment, an apparatus adapted for use with a cleaning solution used to clean a medical device may include a trigger, a processing device in communication with the trigger, and a display device. The processing device provides a trigger count and the display device communicates with the processing device and displays a message based on the count.

Contact lens cleaning system with monitor

This application describes compounds useful as anti-microbial agents, including as antibacterial, disinfectant, antifungal, germicidal or antiviral agents.

Antimicrobial haloalkyl heterocycle compounds

The present application relates to N-chlorinated oxazolidinone, hydantoin and imidazolidinone compounds of Formula I or pharmaceutically acceptable salts thereof, and associated compositions and methods of use as antimicrobial agents.

Antimicrobial oxazolidinone, hydantoin and imidazolidinone compositions

The present application relates to N-chlorinated cationic compounds of Formula I or a salt thereof, and associated compositions and methods of use as antimicrobial agents.

Antimicrobial N-chlorinated compositions

Described herein are N-hydroxyamide antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical compositions compound of Formula (I): or a salt, solvate ti hydrate thereof, wherein A is (a) eachindicates a point of attachment. 

N-hydroxyamide derivatives possessing antibacterial activity

Novel N-formyl hydroxylamine compounds of formula I: wherein

N-formyl hydroxylamines compounds

Novel N-formyl hydroxylamine compounds and their derivatives are disclosed. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed.

N-formyl hydroxylamines

Growing community of inventors

Fremont, CA, United States of America

Charles Francavilla