Depuy Synthes Products, Inc.

Charles Florek

David A Armbruster

Stanley J Kmiec, Jr

Junior Julien

Eric M Cozzone

Kyra Woloszczuk

Michael Good

Malavosklish Bikram-Liles

Shireen Shaikh

Geoffrey Navarro Vale

Stanley J Kmiec Jr

Provided are orthopedic implants and systems and kits containing orthopedic implants that include biodegradable polymer thin films containing an antimicrobial agent, wherein the implants produce an effective zone of inhibition around a periphery of the surface of the implant and do not produce a loss of release torque between interlocking implant components.

Ultrathin films for triclosan transfer to metal medical devices

The present disclosure is directed to temporary antimicrobial-eluting cement spacer implants, and assemblies, kits, and methods for forming the same. Particularly preferred disclosures are to modular spacers, assemblies, and kits, as well as methods of manufacturing the same, where the modular nature of the spacer permits the selection of specific desired length spacers, as well as specific selection of antimicrobial compounds and dosages, along with the components and processes for forming the same.

Temporary antimicrobial cement spacer, assembly, kit, and method of manufacture

Systems, methods of manufacture, and packaging configurations are provided for an antimicrobial orthopedic implant having an antimicrobial coating on the outer surface of the implant including a vaporizable antimicrobial agent in a surface area concentration on the outer surface sufficient to prevent bacterial growth on the orthopedic implant, and can additionally provide a clinically effective zone of inhibition around the orthopedic implant. In certain embodiments, a container, a reservoir of the vaporizable antimicrobial agent, and the orthopedic implant are configured to remain thermally stable in a temperature range up to 200 C.

Systems and methods for forming an antimicrobial orthopedic implant

Provided herein are compositions for treating biofilm-derived infections include a cis-monounsaturated fatty acid solubilized in a solvent with a concentration in the range of about 100 ppm (parts per million) to about 1000 ppm, where the composition is configured to produce a bactericidal effect measured as a log reduction of colony forming units (CFU) of a bacteria of at least 1.0 when the composition is applied to a biofilm formed from the bacteria. Also provided are methods for treating the site of a biofilm-derived infection comprising applying a composition as disclosed herein to the site.

Bactericidal debridement compositions for surgical site infections and chronic wound healing

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Downingtown, PA, United States of America

Charles Florek