Georgetown University

Other

Charles F Hammer

Abdolhossen Talebian

Philip S Schein

Dianna C Green

Robert R Clarke

Alem Ghiorghis

Reinhard Bredehorst

Abdel H Talebian

Carl-Wilhelm Vogel

Fabio Leonessa

The present invention is directed to compounds of formula I ##STR1## wherein the substituents are as defined in the specification. Also disclosed are compositions and method of use of the compounds.

Progesterone analogs to reverse multidrug resistance

The rotor of an electric motor is a crank shaft driven through connecting rods by piston-like reciprocating members powered by superconducting electromagnets. The electromagnets can be solenoids of conventional material cryogenically cooled to superconduct. In the preferred embodiment, the solenoids reside in a thermally insulated chamber filled with liquid gas coolant. The reciprocating members each have a head which is a linearly moveable core of a solenoid The reciprocating members also each have a base which travels in a cylinder defined by a motor block. The motor block can be a conventional block as in an internal combustion engine. A rotating disk having edge commutators electrodes distributes electrical energy to the solenoids in alternating polarity sequences. Sets of solenoids are electrically in parallel to operate in tandem. Conventional internal combustion, piston-driven engines can be modified to be an electric motor as described above.

Reciprocating electric motor

The invention relates to certain derivatives of mitomycins A and C and the use thereof to treat bacterial infections and to supress the growth of cancer cells. The invention also relates to processes for the preparation of the mitomycin derivatives of the invention.

Mitomycin derivatives having reduced bone marrow toxicity, processes for

Compounds of the formula: ##STR1## wherein each of R.sub.1 and R.sub.2 is independently selected from the group consisting of halogen, hydroxy, or mono carboxylic acid or R.sub.1 and R.sub.2 together is a multifunctional carboxylic acid residue which forms a ring with the platinum atom through two oxygens of said multifunctional carboxylic acid; R.sub.3 is a deoxy mono or disaccharide or a derivative thereof; and R.sub.4 is selected from the group consisting of hydrogen, C.sub.1-4 -alkyl, phenyl, benzyl, substituted phenyl or substituted benzyl, wherein substituents are selected from the group consisting of halogen, nitro, C.sub.1-2 -alkoxy, carboxy, carbony ester or phenyl or a pharmaceutically acceptable salt thereof are disclosed. Compositions containing these compounds and methods using these compounds are also discussed.

Platinum compounds suitable for use as pharmaceuticals

Platinum compounds of the formulae: ##STR1## are disclosed. Compositions containing these compounds and methods of using the same in the treatment of tumors are also discussed.

Platinum pharmaceuticals

This invention provides for a cephalosporin immobilized on a solid phase support comprising a beta-lactamase releasable, detectably labeled substituent at the 3-position thereof. This invention also provides for an assay for detecting the presence of beta-lactamase enzyme in a sample comprising:

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Washington, DC, United States of America

Charles F Hammer