Minnesota Mining and Manufacturing Company

3m Innovative Properties Company

Charles E Shelburne

Sumita Basu Mitra

Sharon M Rozzi

Brant L Kedrowski

Gregory D Cuny

Terrance P Smith

Kevin D Landgrebe

Mark A Tomai

The disclosure provides methods for the treatment and prevention of periodontal disease. In preferred embodiments, the invention provides for local treatment of periodontal tissues with a pharmaceutical composition including an immune response modifier (IRM) selected from the group of immune response modifiers comprising imidazoquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, imidazonaphtyridine amines, oxazoloquinoline amines, thiazoloquinoline amines and 1,2-bridged imidazopyridine amines.

Methods for the treatment of periodontal disease

Coatings for hard tissue and surfaces of the oral environment are provided that reduce adhesion of bacteria and proteinaceous substances to these surfaces. Methods of reducing adhesion of these materials to such surfaces, and polymers for incorporation into such coatings are also provided.

Optionally crosslinkable coatings, compositions and methods of use

This invention relates to the use of compounds having the general structure:

Method for limiting the growth of microorganisms using metal-containing compounds

Optionally crosslinkable coatings compositions and methods of use

Fluorocarbon containing coatings, compositions and methods of use

Hydrocarbyl containing coatings, compositions and methods of use

A reliable, rapid, inexpensive and noninvasive method is provided for the diagnosis of Lyme disease by the detection of antigens of the spirochete responsible for that disease, Borrelia burgdorferi, in the urine of an affected individual.

Method and composition for the diagnosis of Lyme disease

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Brooklyn Park, MN, United States of America

Charles E Shelburne