Nanobiomagnetics, Inc.

The University of Oklahoma

Nanomateriales S.a. De C.v.

USA As Represented by Secretary of the Navy

Kerr-mcgee Chemical, LLC

Swr&d Inc.

Charles E Seeney

William A Yuill

Kenneth J Dormer

Donald D Gibson

Richard Dana Kopke

Jim Klostergaard

Tanna K Watson

A single step milling and surface coating process allows for production of a stable dispersion of surface coated nanoparticles in an efficient manner. The process comprises providing feed particles, providing a coating agent, and generating the stable dispersion of surface coated nanoparticles by milling the feed particles in an aqueous medium containing the coating agent such that the coating agent bonds to surfaces of the feed particles as the feed particles are milled to an average particle size of less than about 100 nm.

Single step milling and surface coating process for preparing stable nanodispersions

Magnetically responsive therapeutic carriers comprise nanoparticles including single-domain nanoparticles comprising magnetite and having an average particle size ranging between 1 and 50 nanometers, clusters of the single-domain nanoparticles, the clusters having an average cluster size ranging between 5 and 1000 nanometers, and mixtures of the two. The single-domain nanoparticles are encapsulated with a silica coating. A silane coupling agent is bonded to the silica coating and has a specific pendant functional group capable of selectively binding with the therapeutic. Preferably, the bond between the specific pendant functional group and the therapeutic is a covalent bond. The movement of magnetically responsive nanoparticle therapeutic constructs, with concentration and extravasation/endocytosis at a target site, such as cancerous tumors, uses a controllable magnetic field generator adapted to move the therapeutic constructs in three dimensions, and is enhanced using a repetitively-varying magnetic field. A method for treating cancer comprises administering and magnetically guiding a therapeutic construct comprising paclitaxel.

Magnetically responsive nanoparticle therapeutic constructs and methods of making and using

The movement of magnetically responsive nanoparticles through a membrane is significantly enhanced by using a varying magnetic field gradient. The magnetic field varies in intensity and/or direction and can be achieved by mechanically varying the position of a magnet with respect to the membrane, or by oscillating the strength of one or more electromagnets.

Device for moving magnetic nanoparticles through tissue

A system and method for affecting the function of a mammalian ear. The system and method uses an oscillating magnetic field to move nanospheres comprised of single-domain nanoparticles. In a preferred embodiment a receiving assembly detects sound waves and transmits the sound waves to a processor. The processor drives an electromagnetic coil in response to the detected sound waves. The electromagnetic coil transmits a signal that causes vibration of the nanoparticles and the tissues within which the nanoparticles are implanted.

Method and apparatus for improving hearing

A system for introducing a bioactive substance into a target cell within a body. The bioactive substance is transported to the target cell using a superparamagnetic nanoparticle and a controllable magnetic field generator that is capable of moving the nanoparticle to the target cell through the body in three dimensions. The nanoparticle may be covered with a biocompatible shell that forms a covalent bond with the bioactive substance. In an alternative embodiment, the bioactive substance and a plurality of nanoparticles are supported by a bioerodable matrix that forms a nanosphere. The nanosphere may be moved into the target cell using an external magnetic field that is controllable to move the nanosphere in three dimensions through the body and the bioactive substance is released from the nanosphere once inside the target cell.

Delivery of bioactive substances to target cells

The present invention provides modified particulate metal oxides having desired properties and methods of producing the metal oxides. The methods basically comprise the steps of reacting a particulate metal oxide in an aqueous solution or emulsion containing ceric ion to produce hydroxyl free radicals on the surfaces of the metal oxide and then reacting the metal oxide with a polymerizable vinyl monomer to graft the monomer to the metal oxide and polymerize the monomer. The graft polymerized metal oxide compositions produced have improved properties such as compatibility and ease of mixing with water based, oil based and plastics formulations.

Growing community of inventors

Edmond, OK, United States of America

Charles E Seeney