The United States of America As Represented by the Department of Health

The United States of America As Represented by the Secretary of

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Charles E Myers

Jane B Trepel

Cy A Stein

Farzaneh Pirnia

Wei-Gang Fang

Renato V LaRocca

Dvorit Samid

Edward A Sausville

Len Neckers

Chi-Wan Chen

Jack S Cohen

McClellan M Walther

Adi F Gazdar

Alexandra Miller

Herbert K Oie

Won Ki Kang

Gregory Curt

Renato V La Rocca

Gershon Y Locker

Luke Whitesell

Miriam Sohn

James H Doroshow

W Marston Linehan

Michael R Cooper

Methods of treating various cancers, such as prostatic adenocarcinoma, with inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG Co-A), such as lovastatin, are provided. Dosing ranges, schedules and toxicities are included.

Use of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase as

Protector for wrist watch lens or the like

Protector for wrist watch lens

Continuous cell lines have been established from adrenocortical corcinomas. The cell lines are maintained in fully defined serum-free, steroid-free mediums. The cells of the invention, as exemplified by NCI-H295 cells, express all of the major pathways of steroid-ogenesis, including formation of corticosteroids, mineralocorticoids and androgens.

Steroid secreting human adrenocortical carcinoma cell lines

The instant invention is directed to the use of a pharmaceutical composition containing an effective amount of adenosine or an adenosine analog or derivative as an agent useful in the treatment of hormone-independent cancers, such as prostate cancer. The invention is also directed to diagnostic uses of these compounds to determine effective treatment regimes for specific tumors, a process for screening for new, therapeutically useful analogs of these compounds, and the use of these compounds in facilitating the extraction of intracellular components.

Use of purinergic receptor agonists as antineoplastic agents

The invention provides methods of treating cancer including administering an effective amount of selected terpenes to a mammal having the cancer when the cancer is prostate cancer, colon cancer, astrocytoma, or sarcoma. The terpene is selected from the group consisting of a cyclic monoterpene, a noncyclic monoterpene, a noncyclic sesquiterpene and a noncyclic diterpene. The invention also provides a method of sensitizing a cancer to radiation including administering an effective amount of a terpene to a mammal having the cancer wherein the terpene is selected from the group noted above. Additionally, the invention provides methods of inhibiting the growth of cancer cells including applying an effective amount of a selected terpene to the cancer cells which are cells of prostate cancer, colon cancer, osteosarcoma, or glioblastoma.

Monoterpenes, sesquiterpenes and diterpenes as cancer therapy

A method is disclosed for the treatment of hypercalcemia in a patient, by administering to the patient an effective amount of suramin, or an active analogue thereof, for lowering calcium plasma levels in the patient. Human data shows a single course of treatment lowers plasma calcium levels to normal for three months.

Suramin and active analogues thereof in the treatment of hypercalcemia

Polysulfonated compounds such as suramin are used to treat immunoregulatory isorders. Particular use in the treatment of rheumatologic diseases such as rheumatoid arthritis is shown.

Use of suramin to treat rheumatologic diseases

Water-soluble paramagnetic metalloporphyrins are used as contrast enhancing agents for magnetic resonance imaging. These agents exhibit excellent localization, non-toxicity and suprisingly high contrast enhancement in magnetic resonance imaging applications.

Use of paramagnetic metalloporphyrins as contrast agents for tumors in

The cardiac damage, occurring after treatment with an anthracycline, such as adriamycin, is prevented when N-acetyl-cysteine is orally administered about one hour prior to the treatment with the anthracycline.

N-Acetyl-cysteine protects against cardiac damage from

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Rockville, MD, United States of America

Charles E Myers