Pfizer Corporation

The Dow Chemical Company

Charles E Moppett

Walter P Cullen

Walter D Celmer

Riichiro Shibakawa

Junsuke Tone

John B Routien

John R Oscarson

Mark T Jefferson

Liang H Huang

Albertha M Paul

Wendell W Windisch

Frank C Sciavolino

William W Armstrong

Paul C Watts

Eugene F Fiese

John R Routien

Junsuki Tone

Transformation product of thiosporamicin

The 1:2 N,N'-dibenzylethylenediamine, the N-benzyl-2-phenylethylamine and the dibenzylamine salts of penicillanic acid 1,1-dioxide, a well-known betalactamase inhibitor, are sparingly soluble in water. Accordingly they are valuable as slow release (depot) forms of penicillanic acid 1,1-dioxide, particularly for use in conjunction with slow release (depot) forms of penicillin and cephalosporin antibiotics, in the chemotherapy of bacterial infections in mammals.

Sparingly water-soluble salts of penicillanic acid 1,1-dioxide

A species of Actinoplanes, designated Actinoplanes deccanensis Parenti, Pagani and Beretta subsp. salmoneus Huang subsp. nov., ATCC 31355, when subjected to submerged aerobic fermentation, produces a new antibiotic complex. Methods for the recovery and purification of the antibiotic complex and some of the individual antibiotic components are described.

Antibiotics produced by species of actinoplanes

A new polycyclic ether antibiotic produced by a strain of Streptomyces hygroscopicus under submerged fermentation conditions is useful in controlling coccidiosis in poultry and in improving feed utilization efficiency in ruminants.

Polycyclic ether antibiotic produced by a strain of streptomyces

A new species of Nocardia, designated Nocardia argentinensis Huang sp. nov., when subjected to aerobic submerged fermentation, produces a mixture of new antibiotics. Methods for the recovery and purification of these antibiotics are described and some of their antimicrobial properties are outlined.

Antibiotics produced by new species of nocardia

A species of Actinoplanes, designated Actinoplanes auranticolor ATCC 31011, when subjected to submerged aerobic fermentation under controlled conditions, produces a mixture of antibiotics which includes a number of macrocyclic lactones and depsipeptides. The individual compounds exhibit significant antibiotic activity. The crude antibiotic mixture or combinations of a pure macrocyclic lactone and a pure depsipeptide demonstrate marked synergistic antibiotic activity. These antibiotics act as growth promotants in chicks and swine and are effective in the treatment of swine dysentery. This mixture of antibiotics is also produced by a species of Actinoplanes designated Actinoplanes azureus ATCC 31157. In addition, this culture produces a mixture of heptaene antibiotics with antifungal properties.

Mixture of antibiotics produced by a species of actinoplanes

New polycyclic ether antibiotics produced by a species of actinomycete under submerged fermentation conditions are useful in controlling coccidiosis in poultry and in improving feed utilization efficiency in ruminants.

Polycyclic ether antibiotics produced by new species of actinomycete

A new polycyclic ether antibiotic with anticoccidial, antimicrobial and growth promotant properties, its production by fermentation and methods for its recovery and purification are described.

Polycyclic ether antibiotic

A new sulfur-containing polypeptide antibiotic produced by two strains of Streptosporangium under submerged fermentation conditions is useful for the treatment of microbial infections and in improving feed utilization efficiency in ruminants.

Polypeptide antibiotic produced by a new subspecies of streptosporangium

A new polycyclic ether antibiotic produced by three strains of a new species of Dactylosporangium under submerged fermentation conditions is useful in controlling coccidiosis in poultry and in improving feed utilization efficiency in ruminants.

Polycyclic ether antibiotic produced by new species of dactylosporangium

A new polycyclic ether antibiotic with anticoccidial, insecticidal and antimicrobial activity, its production by fermentation and methods for its recovery and purification are described.

Compounds of the formula ##STR1## where X represents O or S and R represents C.sub.1-4 alkyl, phenyl or (C.sub.1-4 alkyl)phenyl. The compounds are prepared by reacting the ring-opened intermediate, obtained by reacting cis-1-(3-chloro-2-propenyl)-3,5,7-triaza-1-azoniatricyclo (3.3.1.1.sup.3,7) decane chloride with excess aqueous sodium hydroxide, with an equivalent amount of a corresponding halide formate or halide thioformate, ClC=X(OR), at about 0.degree. C in the presenceof a hydrogen chloride acceptor and using a non-nucleophilic organic solvent as reaction medium. The carbamate products have antimicrobial utility.

3-Carboalkoxy (or phenoxy) and

Compounds of the formula ##STR1## where X represents O or S and R.sub.1 and R.sub.2 each represents lower alkyl, phenyl or (lower alkyl)phenyl. The compounds are prepared by reacting the ring-opened intermediate (obtained by reacting cis-1-(3-chloro-2-propenyl)-3,5,7-triaza-1-azoniatricyclo(3.3.1.1.sup.3,7) decane chloride with excess aqueous sodium hydroxide) with an equivalent amount of a corresponding carbamoyl halide or thiocarbamoyl halide or at a low temperature to give the indicated tetrasubstituted urea or thiourea product. The compounds have antimicrobial utility.

N,N-disubstituted derivatives of 3-carboxamide or

Polycyclic ether antibiotic for combating insects

A new species of Micromonospora, designated Micromonospora saitamica sp. nov. Routien, when subjected to submerged aerobic fermentation, produces at least four antibiotics. One of these is previously reported rubradirin produced by Streptomyces achromogenes var. rubradiris NRRL 3061.

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Mystic, CT, United States of America

Charles E Moppett