Cellegy Pharmaceuticals Inc.

American Home Products Corporation

Benchtop Machine and Instrument, Inc.

Cellergy Pharmaceuticals, Inc.

Charles E Lee

Jung-Chung Lee

Thomas P Parks

Vivien Mak

Shamim Pushpala

John D Della-Santina

A dispensing device includes a hollow body coupled to a pump mechanism having a dip tube, and to a follower piston. A well provided in the piston is generally larger in diameter than the dip tube to allow fluid in the chamber to flow down into the well as the dip tube enters the well to facilitate fluid removal after a significant portion of the fluid has been removed. In some aspects, the well walls and dip tube end are substantially conical shaped with the well walls substantially parallel to the dip tube end or having a greater angle relative to the axis of the dip tube

Taper well meter dose pump

Compositions and methods for the treatment of anorectal disorders are provided in which certain combinations of NO donors, PDE inhibitors, superoxide (O ) scavengers, &bgr;-adrenergic agonists, cAMP-dependent protein kinase activators, &agr; -adrenergic antagonists, L-type Ca channel blockers, estrogens, ATP-sensitive K channel activators and smooth muscle relaxants are used.

Compositions and methods for the treatment of anorectal disorders

An entrapped gas measuring apparatus includes a reservoir housing with a reservoir which is adapted to receive a material sample and to expand according to an expansion of the material sample when a negative pressure is applied externally to the reservoir. A parameter indicating the change in volume of the reservoir during the expansion, such as the actual change of volume of the reservoir or a change in position of a moveable wall which at least in part defines the reservoir, is detected by a detector. A processor coupled to the detector is used to determine the amount of entrapped gas based upon the detected parameter. The amount of entrapped gas determined by the processor may be the percent volume of the entrapped gas in relation to the overall volume of the sample, or may be the actual volume of the entrapped gas in the sample. Based at least in-part upon the measured amount of entrapped gas within the sample, the processor is further adapted to determine at least one of: percent volume of the substrate in the sample in relation to the overall volume of the sample; actual volume of the substrate in the sample; or density of the sample or substrate within the sample. The entrapped gas measuring apparatus may be used to produce a material having a known amount of entrapped gas by: making a first material according to a first method and which has a first amount of entrapped gas; applying a negative pressure to the sample such that the sample expands from a first volume to a second volume; detecting a parameter which is indicative of the change of sample volume under the applied negative pressure; comparing the detected parameter with a predetermined range for the parameter; and, if the detected parameter is not within the predetermined range, making a second material according to a second method which has a second amount of entrapped gas that is within the predetermined range.

Apparatus and method for determining the amount of entrapped gas in a

This invention relates to coating formulations for coating sustained-release drug implants. The coating formulations are capable of formulations are capable of forming a porous film coat over a biologically active agent to provide a release of the active agent at a constant rate over a prolonged period of time. The pore forming agent is used in the formulation of the invention in the amount effective to regulate the release of a biologically active compound at a desired rate. Preferably, the effective amount of the pore forming agent provides long term delivery of the active agent. The invention also provides an improved implant for the sustained administration of a biologically active compound suitable for subcutaneous implantation. The invention also relates to methods for making and using the formulation and the implant of the invention.

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Union City, CA, United States of America

Charles E Lee