Zymogenetics, Inc.

Biomimetic Therapeutics, LLC

Novo Nordisk A/s

Other

University of Washington

Charles E Hart

Debra G Gilbertson

Paul O Sheppard

Samuel E Lynch

Zeren Gao

Lars Christian Petersen

Christopher S Piddington

Stavros Topouzis

Ulla Hedner

Kimberly E Shoemaker

Teresa Gilbert

Kathleen L Berkner

James William West

Claus Bregengaard

Conan S Young

Mirella Ezban Rasmussen

Jeffrey O Hollinger

Michael G Ehrlich

Douglas C Moore

Joshua Nickols

Dan Perrien

Alexander W Clowes

Richard D Kenagy

Scott R Presnell

Mark W Orme

Robert R West

Theresa Martinez

Joyce M Lehner

Kimberty E Shoemaker

Oliver J McConnell

Kristen M Moynihan

The present invention relates to compositions and methods useful for treating structures of the vertebral column, including vertebral bodies. In one embodiment, a method for promoting bone formation in a vertebral body comprising providing a composition comprising a PDGF solution and a biocompatible matrix and applying the composition to at least one vertebral body. Promoting bone formation in a vertebral body, according to some embodiments, can increase bone volume, mass, and/or density leading to an increase in mechanical strength of the vertebral body treated with a composition of the present invention.

Compositions and methods for treating the vertebral column

The present invention provides compositions and methods for attaching tendon to bone. The present invention provides compositions and methods for treating rotator cuff injuries. In one embodiment, a method for treating rotator cuff injuries comprises providing a composition comprising PDGF disposed in a biocompatible matrix and applying the composition to at least one site of tendon reattachment on the humeral head.

Compositions and methods for treating rotator cuff injuries

The present invention relates to compositions, methods and kits for the treatment of bone particularly impaired or damaged bone.

Compositions and methods for treating bone

Materials and methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.

Methods of treating fibroproliferative disorders of the kidney or reducing kidney fibrosis

Materials and Methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.

Method of treating fibroproliferative disorders of the heart and lung

The present invention provides compositions and methods for facilitating fusion of bones in a joint. The present invention provides compositions and methods for promoting fusion of bones in arthrodetic procedures. In one embodiment, a method of performing an arthrodetic procedure comprises providing a composition comprising PDGF disposed in a biocompatible matrix and applying the composition to a site of desired bone fusion in a joint.

Compositions and methods for arthrodetic procedures

The present invention relates to compositions and methods for use in osteodistraction procedures. In one embodiment, a method of stimulating osteogenesis during and/or following bone distraction comprises providing a composition comprising a PDGF solution disposed in a biocompatible matrix and applying the composition to at least one site of bone distraction.

Methods for treatment of distraction osteogenesis using PDGF

Method of treating fibrproliferative disorders

Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

Growth factor homolog ZVEGF3

Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

Methods of stimulating bone growth using ZVEGF4 polypeptides

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Woodinville, WA, United States of America

Charles E Hart