Wisconsin Alumni Research Foundation

Other

Charles E Elson

Michael N Gould

Huanbiao Mo

Pamela L Crowell

Asaf A Qureshi

Patricia M Hentosh

Zhibin Ren

Steven S Clark

Warren C Burger

Dennis M Peffley

Manfred Jung

A composition and an associated method of treating cancer cells by impeding cancer cell growth with the composition are disclosed. The composition includes at least a first and a second HMG-CoA reductase inhibitor, wherein the total amount of the first and second HMG-CoA reductase inhibitors is effective in synergistically impeding cancer cell growth and wherein the cancer cell growth synergistic impedance from the total amount of the first and second HMG-CoA reductase inhibitors is greater than a theoretical additive effect from the combined first and second HMG-CoA reductase inhibitors. The present composition does not simultaneously contain both a tocotrienol and an ionone when the composition contains only a first and a second HMG-CoA reductase inhibitor. The method includes treating cancer cells with the claimed composition to impede cancer cell growth.

Composition and method for treating cancer

A method of and compositions for suppressing the growth of tumor cells in a patient are disclosed. In one embodiment, the method comprises treating the patient with an effective amount of an isoprenoid ether-linked compound, wherein the isoprenoid ether-linked compound comprises a first acyclic isoprenoid molecule linked via an ether linkage to a second molecule, wherein the second molecule can suppress tumor formation.

Acyclic isoprenoid ether derivatives as chemotherapeutics

A method of inhibiting the growth of tumor cells is disclosed. In one embodiment, this method comprises the step of exposing tumor cells to an effective amount of a composition comprising at least two compounds selected from the group consisting of tocotrienols, statins and ionones.

Method of suppressing tumor growth with combinations of isoprenoids and statins

A method of inhibiting or preventing the growth of tumor cells is disclosed. In one embodiment, this method comprises the step of administering a compound selected from the group consisting of citracetal, citral dimethyl acetal, citral diethyl acetal, geranyl benzoate, geranyl tiglate, geranyl anthranilate, farnesyl benzoate, farnesyl anthranilate, farnesyl tiglate, farnesyl acetate and combinations thereof to a human tumor patient, wherein the amount is effective to reduce or inhibit tumor growth by at least 50%.

Acyclic monoterpenoid derivatives

Method of suppressing tumor growth with combinations of isoprenoids and

A method for causing regression of a leukemia cell tumor is disclosed. This method comprises the step of administering perillyl alcohol to a tumor-containing mammal.

Regression of mammalian leukemia cell tumors

A method of causing carcinoma regression is disclosed. One administers an effective amount of perillic acid methyl ester. The use of perillic acid methyl ester is disclosed. A pharmaceutical composition involving perillic acid methyl ester is disclosed.

Uses of perillic acid methyl ester

A method for causing regression of a carcinoma is disclosed. This method comprising the step of administering to a carcinoma-containing mammal an effective amount of a compound of the formula: ##STR1## This formula represents perillyl alcohol.

Regression of mammalian carcinomas

A method of lowering cholesterol comprises administering to an animal safe and effective amounts of d-.alpha.-tocotrienol. A method of extracting d-.alpha.-tocotrienol from natural sources and pharmaceutical compositions containing d-.alpha.-tocotrienol are also disclosed.

Growing community of inventors

Madison, WI, United States of America

Charles E Elson